Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71

Journal of Cellular Biochemistry
Julia KnebelR Janknecht

Abstract

Testis-specific gene A (TSGA) was originally identified in rat and shown to be expressed within the testes. Here, we have cloned the murine homolog [also known as jumonji domain-containing 1a (Jmjd1a)] and for the first time characterized the TSGA protein and its functions. Although murine TSGA is expressed in testes, its mRNA is also present in many other tissues, including heart, thymus, liver, and skin. Immunostaining revealed that TSGA is a nuclear protein, whose N-terminus contains a putative nuclear localization signal. TSGA displays significant homology to a suspected tumor suppressor and coactivator (5qNCA), to a thyroid hormone receptor interacting protein (TRIP8) and to the corepressor Hairless, pointing at a role of TSGA in transcription regulation. Indeed, TSGA contains several functional transcription repression domains. In addition, TSGA interacts both in vitro and in vivo with ER71 (ETS related 71), a transcription factor that is expressed in the testes of adult mice and during embryogenesis. Specifically, the N-terminus of TSGA and the C-terminus of ER71 are primarily engaged in their complex formation. Furthermore, TSGA impairs the ability of ER71 to activate transcription from the matrix metalloproteinase-1 pr...Continue Reading

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Citations

Jul 29, 2010·The Journal of Biological Chemistry·Steven M MooneyRalf Janknecht
May 23, 2012·The Journal of Biological Chemistry·Luciano DiTacchioRalf Janknecht
Nov 6, 2008·The Journal of Biological Chemistry·Sophie BeyerPeter Staller
Aug 21, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jessica A WarnsArchana Dhasarathy
Dec 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rimpei MoritaAkihiko Yoshimura
Sep 25, 2010·Biochemical and Biophysical Research Communications·Joanna KimRalf Janknecht
Oct 23, 2009·Annals of the New York Academy of Sciences·Jun YangAdrian L Harris
Aug 30, 2008·Journal of Cellular Biochemistry·Sook ShinRalf Janknecht
Dec 3, 2011·Journal of Cellular Biochemistry·Tae-Dong KimRalf Janknecht
Jun 10, 2008·Biochemical and Biophysical Research Communications·Sven WellmannChristoph Bührer
Dec 15, 2007·Biochemical and Biophysical Research Communications·Tae-Dong KimRalf Janknecht
Sep 29, 2011·Seminars in Cell & Developmental Biology·Stryder M MeadowsPaul A Krieg
Jun 9, 2007·Biochemical and Biophysical Research Communications·Sook Shin, Ralf Janknecht
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Aug 19, 2007·Cancer Research·Sook ShinRalf Janknecht
Jul 2, 2020·Molecular Cancer Research : MCR·Yuan SuiRalf Janknecht

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