Reprint of: Acute Graft-versus-Host Disease: Novel Biological Insights

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
T TeshimaRobert Zeiser

Abstract

Graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Recent insights into intestinal homeostasis and uncovering of new pathways and targets have greatly reconciled our understanding of GVHD pathophysiology and will reshape contemporary GVHD prophylaxis and treatment. Gastrointestinal (GI) GVHD is the major cause of mortality. Emerging data indicate that intestinal stem cells (ISCs) and their niche Paneth cells are targeted, resulting in dysregulation of the intestinal homeostasis and microbial ecology. The microbiota and their metabolites shape the immune system and intestinal homeostasis, and they may alter host susceptibility to GVHD. Protection of the ISC niche system and modification of the intestinal microbiota and metabolome to restore intestinal homeostasis may, thus, represent a novel approach to modulate GVHD and infection. Damage to the intestine plays a central role in amplifying systemic GVHD by propagating a proinflammatory cytokine milieu. Molecular targeting to inhibit kinase signaling may be a promising approach to treat GVHD, ideally via targeting the redundant effect of multiple cytokines on immune cells and entero...Continue Reading

References

Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·S E NicholsonJ E Layton
Feb 23, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret L MacMillanBruce R Blazar
Jun 4, 2002·Nature Medicine·Takanori TeshimaJames L M Ferrara
Apr 8, 2004·Blood·Daniel CourielRichard Champlin
Aug 20, 2005·Science·Kyung-Ah KimKazuma Tomizuka
Apr 25, 2006·Journal of Clinical Gastroenterology·Julia M W WongDavid J A Jenkins
May 16, 2007·The Journal of Biological Chemistry·Christian SchindlerThomas Decker
Jul 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marc SchnitzlerJürgen Finke
Jul 15, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bo TangLinda K Myers
Mar 30, 2010·Bone Marrow Transplantation·N SchubR Repp
Apr 1, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nathan CantoniMartin Stern
May 11, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Walter J F M van der VeldenNicole M A Blijlevens
Feb 2, 2011·The Journal of Experimental Medicine·Shuichiro TakashimaTakanori Teshima
Nov 15, 2011·Current Opinion in Gastroenterology·Vincent B Young
Apr 19, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paul J MartinPaul A Carpenter
May 2, 2012·The Journal of Experimental Medicine·Robert R JenqMarcel R M van den Brink
Jun 22, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying TaurEric G Pamer
Jul 13, 2012·The New England Journal of Medicine·Ran ReshefDavid L Porter
Sep 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Isao TawaraPavan Reddy
Sep 25, 2012·Nature Cell Biology·Johan H van EsHans Clevers
Jan 10, 2013·Blood·Steffen HartrampfMarcel R M van den Brink
Jan 18, 2013·Blood·Pawel Muranski, Nicholas P Restifo
Feb 18, 2014·Blood·Jessica L AllenStefanie Sarantopoulos
Apr 1, 2014·Journal of Dermatological Science·Doanh Le HuuTakashi Matsushita
Apr 9, 2014·Blood·Silvia SpoerlNikolas von Bubnoff

❮ Previous
Next ❯

Citations

Mar 19, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Armin RashidiRizwan Romee
Sep 28, 2017·The Journal of Experimental Medicine·Barbara Maximino RezendeVanessa Pinho
Aug 23, 2017·Nature Communications·Satish RanjanBerend Isermann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
T TeshimaRobert Zeiser
International Journal of Hematology
Yusuke ShonoRobert R Jenq
Survey of Ophthalmology
Hasanain ShikariReza Dana
© 2022 Meta ULC. All rights reserved