Reprint of "Concepts derived from the Challenge Hypothesis".

Hormones and Behavior
John C WingfieldK K Soma

Abstract

The Challenge Hypothesis was developed to explain why and how regulatory mechanisms underlying patterns of testosterone secretion vary so much across species and populations as well as among and within individuals. The hypothesis has been tested many times over the past 30years in all vertebrate groups as well as some invertebrates. Some experimental tests supported the hypothesis but many did not. However, the emerging concepts and methods extend and widen the Challenge Hypothesis to potentially all endocrine systems, and not only control of secretion, but also transport mechanisms and how target cells are able to adjust their responsiveness to circulating levels of hormones independently of other tissues. The latter concept may be particularly important in explaining how tissues respond differently to the same hormone concentration. Responsiveness of the hypothalamo-pituitary-gonad (HPG) axis to environmental and social cues regulating reproductive functions may all be driven by gonadotropin-releasing hormone (GnRH) or gonadotropin-inhibiting hormone (GnIH), but the question remains as to how different contexts and social interactions result in stimulation of GnRH or GnIH release. These concepts, although suspected for many d...Continue Reading

References

Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C CorpéchotE E Baulieu
Jan 1, 1994·Psychoneuroendocrinology·J C Wingfield
Jul 8, 2000·Proceedings. Biological Sciences·K K SomaJ C Wingfield
Oct 4, 2000·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·K K SomaJ C Wingfield
Aug 3, 2001·General and Comparative Endocrinology·K K Soma, J C Wingfield
Oct 20, 2001·Brain, Behavior and Evolution·J C WingfieldK K Soma
Mar 5, 2003·Hormones and Behavior·Bruce S McEwen, John C Wingfield
Oct 13, 2004·The American Naturalist·Wolfgang GoymannJohn C Wingfield
May 18, 2005·Hormones and Behavior·James L GoodsonKiran K Soma
Jun 28, 2005·Hormones and Behavior·Temitayo O Oyegbile, Catherine A Marler
Jul 6, 2005·Hormones and Behavior·John C Wingfield
Nov 19, 2005·The Journal of Endocrinology·F LabrieC Labrie
Jun 16, 2006·Journal of Neuroendocrinology·K K Soma
Jan 18, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michaela Hau
Apr 3, 2007·Hormones and Behavior·Ignacio T Moore
Jul 24, 2007·Neurochemistry International·Barney A SchlingerKiran K Soma
Oct 19, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M Vogeser, K G Parhofer
Oct 20, 2007·Biological Reviews of the Cambridge Philosophical Society·Shinichi Nakagawa, Innes C Cuthill
Feb 7, 2008·Proceedings. Biological Sciences·Wolfgang GoymannMusa Makomba
Feb 19, 2008·Frontiers in Neuroendocrinology·Kiran K SomaGregory E Demas
May 20, 2008·General and Comparative Endocrinology·Kim L SchmidtKiran K Soma
Sep 30, 2008·Nature Neuroscience·Luke Remage-HealeyBarney A Schlinger
Dec 23, 2008·General and Comparative Endocrinology·Wolfgang Goymann
May 28, 2009·Hormones and Behavior·L Michael RomeroNicole E Cyr
May 29, 2009·The European Journal of Neuroscience·Amy E M Newman, Kiran K Soma
Oct 1, 2009·Integrative and Comparative Biology·Ellen D KettersonJoel W McGlothlin
Feb 1, 2002·Integrative and Comparative Biology·John C Wingfield, Kiran K Soma
Jan 1, 2011·Frontiers in Endocrinology·Matthew D TavesKiran K Soma
Oct 19, 2013·Analytical Chemistry·Diego F CobiceRuth Andrew
Jun 15, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Kiran K SomaGregory E Demas

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Citations

Dec 5, 2020·Developmental Psychobiology·Randy CorpuzGillian K S Collom
Sep 17, 2020·Hormones and Behavior·Donna L ManeySoojin V Yi

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