Reprint of: Highthroughtput analysis of behavior for drug discovery

European Journal of Pharmacology
Vadim AlexandrovEmer Leahy

Abstract

Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three comprehensive highthroughtput systems, SmartCube(®), NeuroCube(®) and PhenoCube(®) systems, to increase the efficiency of the drug screening and phenotyping in rodents. These three systems capture different domains of behavior, namely, cognitive, motor, circadian, social, anxiety-like, gait and others, using custom-built computer vision software and machine learning algorithms for analysis. This review exemplifies the use of the three systems and explains how they can advance drug screening with their applications to phenotyping of disease models, drug screening, selection of lead candidates, behavior-driven lead optimization, and drug repurposing.

References

Jan 28, 2003·Drug Discovery Today·Dani BrunnerEmer Leahy
Jun 28, 2011·Nature Reviews. Drug Discovery·David C Swinney, Jason Anthony
Mar 27, 2012·Drug Discovery Today·Amit TanejaOscar Della Pasqua
Sep 10, 2014·Nature Biotechnology·Marcus MunafòRobi Blumenstein

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Citations

Nov 11, 2019·Pharmacology, Biochemistry, and Behavior·Walter E KaufmannChristopher U Missling
Jul 4, 2019·Journal of Medicinal Chemistry·Dean G Brown, Heike J Wobst

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