Reprint of: The prostate cancer genome: Perspectives and potential

Urologic Oncology
Christopher E Barbieri, Scott A Tomlins

Abstract

Prostate cancer has a variable clinical course, and molecular characterization has revealed striking mutational heterogeneity that may underlie the unpredictable clinical behavior of the disease. Advances in technology have resulted in a rapid expansion of our understanding of the genomic events responsible for the development and progression of prostate cancer. In this review, we discuss the genomic alterations underlying prostate cancer, and potential to utilize this knowledge for diagnostic and prognostic benefit. We reviewed the relevant literature, with a focus on recent studies on somatic alterations in prostate cancer. Pathways known to affect tumorigenesis across a wide spectrum of tissues are dysregulated, such as the PI3K pathway, cell cycle control, and chromatin regulation. Lesions more specific to prostate cancer include alterations in androgen signaling, gene fusions of ETS transcription factors, and mutations in SPOP. Accumulating data suggests that prostate cancer can be subdivided based on a molecular profile of these genetic alterations. These findings raise the possibility that prostate cancer could transition from a poorly understood, heterogeneous disease with a variable clinical course to a collection of h...Continue Reading

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May 29, 2016·Research in Veterinary Science·Luis Gabriel Rivera-CalderónRenée Laufer-Amorim
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