Reproducibility and comparability of insulin sensitivity indices measured by stable-label intravenous glucose tolerance test

Diabetic Medicine : a Journal of the British Diabetic Association
Roman HovorkaM A Young

Abstract

We have investigated the reproducibility of (1) insulin sensitivity (S*I) and glucose effectiveness (S*G) as measured by the stable-label (one compartment) minimal model, and (2) insulin sensitivity (S*Ib), plasma clearance rate (PCR), basal hepatic output (HGOb), and total hepatic glucose output (HGO0-240) as measured by the novel stable-label two compartment model of glucose disappearance during labelled intravenous glucose tolerance test (IVGTT) using 6,6-(2)H-glucose. Ten normal male subjects were studied on two occasions one week apart. Both models provided estimates of all indices with acceptable precision (CV of parameter estimates < or =50%). The within subject CVs of S*I and S*Ib were comparable (17% vs 19%) as were the within subject CVs of S*G and PCR (13% vs 16%). A highly significant linear relationship was observed between S*Ib and S*I (0.303 +/- 0.046 ml kg(-1) min(-1) per mU l(-1) vs 13.04 +/- 1.89 10(-4) min(-1) per mU l(-1), y = 0.0037 x + 0.0002, r = 0.90, p < 0.001; mean +/- SE), but not between PCR and S*G (1.98 +/- 0.15 ml kg(-1) min(-1) vs 0.0089 +/- 0.0005 min(-1), rs = 0.34, NS). The two compartment model provided a plausible time-profile of hepatic glucose output during IVGTT, reproducible estimates of...Continue Reading

Citations

Aug 18, 2017·Angewandte Chemie·Jens AtzrodtMarc Reid
Apr 12, 2002·Rapid Communications in Mass Spectrometry : RCM·Leslie J C BluckChristopher J Bates
Jan 13, 2006·Rapid Communications in Mass Spectrometry : RCM·Leslie J C BluckW Andy Coward
Aug 13, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Andrea Mari
Oct 23, 2002·Rapid Communications in Mass Spectrometry : RCM·Allan T ClappertonLeslie J C Bluck
Mar 10, 1999·The American Journal of Physiology·R HovorkaA M Umpleby
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Gianna Toffolo, Claudio Cobelli
Aug 28, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Berit ChristoffersenGiovanni Pacini
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Roman HovorkaRichard H Jones

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