Reproducibility and replicability in zebrafish behavioral neuroscience research

Pharmacology, Biochemistry, and Behavior
Robert Gerlai

Abstract

Reproducibility and replicability are fundamentally important aspects of the scientific method. From time to time the discussion about whether scientific findings are replicable enough flares up. In fact, some recent publications claim we are witnessing a replication crisis. This is a particularly important problem in laboratory organisms that are relatively new, i.e., for which only limited amount of information is available, and for which only a limited number of methods have been developed. The zebrafish is a relative newcomer in behavioral neuroscience. This review considers four distinct reasons as possibly underlying reproducibility issues in behavioral neuroscience studies using the zebrafish. One, publication bias for positive results. Two, statistical issues that surround the question of how to address type 1 and type 2 errors, and how to make statistical inference. Three, inappropriate control of factors that are known to potentially influence results. And four, methodological issues stemming from insufficient understanding of factors that may influence experimental results. The review will mainly focus on experimental issues and solutions, i.e. the latter two reasons listed above. It is not intended to be comprehensi...Continue Reading

Citations

Sep 27, 2018·Aggressive Behavior·Hellen P BarbosaCaio Maximino
Oct 4, 2019·Nature Reviews. Neuroscience·Anand GururajanDavid A Slattery
Jul 24, 2020·The Journal of Experimental Biology·Jack S ThomsonLynne U Sneddon
Feb 16, 2020·Invertebrate Neuroscience : in·Luciana BorrelliGraziano Fiorito
Feb 11, 2020·Stress : the International Journal on the Biology of Stress·Konstantin A DeminAllan V Kalueff
Sep 13, 2020·Physiology & Behavior·Amira AbozaidRobert Gerlai
Jan 14, 2021·Scientific Reports·Carolina BeppiStefan Yu Bögli
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Murilo S de AbreuAllan V Kalueff
Jan 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise E MüllerDenis B Rosemberg
Jun 5, 2021·Neuroscience and Biobehavioral Reviews·Radharani BenvenuttiAngelo Piato
Jun 9, 2021·Zebrafish·Alexis BuatoisRobert Gerlai
May 15, 2020·Physiology & Behavior·Suelen Mendonça SoaresLeonardo José Gil Barcellos
Dec 18, 2021·Behavior Research Methods·Luis M Gómez-Laplaza, Robert Gerlai
Jan 5, 2022·Biological Reviews of the Cambridge Philosophical Society·Carole J LeeCharles R Tyler

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