Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods

Journal of Nuclear Medicine Technology
Takayuki ShibutaniSeigo Kinuya

Abstract

The Patlak-plot and conventional methods of determining brain uptake ratio (BUR) have some problems with reproducibility. We formulated a method of determining BUR using anatomic standardization (BUR-AS) in a statistical parametric mapping algorithm to improve reproducibility. The objective of this study was to demonstrate the inter- and intraoperator reproducibility of mean cerebral blood flow as determined using BUR-AS in comparison to the conventional-BUR (BUR-C) and Patlak-plot methods. The images of 30 patients who underwent brain perfusion SPECT were retrospectively used in this study. The images were reconstructed using ordered-subset expectation maximization and processed using an automatic quantitative analysis for cerebral blood flow of ECD tool. The mean SPECT count was calculated from axial basal ganglia slices of the normal side (slices 31-40) drawn using a 3-dimensional stereotactic region-of-interest template after anatomic standardization. The mean cerebral blood flow was calculated from the mean SPECT count. Reproducibility was evaluated using coefficient of variation and Bland-Altman plotting. For both inter- and intraoperator reproducibility, the BUR-AS method had the lowest coefficient of variation and small...Continue Reading

References

Jan 1, 1992·European Journal of Nuclear Medicine·H MatsudaK Hisada
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A LassenO B Paulson
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·E L BarbierM Décorps
May 11, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Ryo TakeuchiJunji Konishi
Aug 23, 2008·Nihon Hoshasen Gijutsu Gakkai zasshi·Kimie AsaoSatomi Teraoka
Feb 22, 2012·Annals of Nuclear Medicine·Shigeki ItoYasuyuki Yamashita

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