Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

European Journal of Pain : EJP
Pieter S SiebengaGeert Jan Groeneveld

Abstract

Although reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds. A total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal and electrical stimuli were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard deviation by the least squares means. A total of 76 subjects completed the studies. After being administered pregabalin, the subjects' pain tolerance thresholds in the cold pressor and pressure stimulation tests were significantly increased compared to the placebo group. Moreover, the heat pain detection threshold in UVB-irradiated skin was significantly increased in subjects who were administered ibuprofen compared to the placebo group. Variation among all evoked pain tests range...Continue Reading

References

Sep 1, 1987·Perception & Psychophysics·G B Rollman, G Harris
Jul 1, 1995·Journal of Diabetes and Its Complications·D A GelberD A Greene
Jan 1, 1993·Somatosensory & Motor Research·D J TaylorJ D Greenspan
Sep 28, 1999·Scandinavian Journal of Gastroenterology·A M DrewesL Arendt-Nielsen
Jul 24, 2001·European Journal of Pain : EJP·C M HillG Murray
Sep 18, 2001·European Journal of Pain : EJP·R PolianskisL Arendt-Nielsen
Mar 4, 2003·The American Journal of Psychiatry·Atul C PandeMaria Liu-Dumaw
Mar 26, 2003·Neurology·M E ShyUNKNOWN Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
Jun 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Peter Siao, Didier P Cros
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Romanas PolianskisLars Arendt-Nielsen
Dec 23, 2003·Scandinavian Journal of Gastroenterology·A M DrewesL Arendt-Nielsen
Feb 9, 2005·Neurology·A BeydounUNKNOWN Pregabalin 1008-009 Study Group
Jan 28, 2006·The Journal of Headache and Pain·Stuart Cathcart, Donald Pritchard
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Camilla StaahlAsbjørn Mohr Drewes
Dec 11, 2007·Muscle & Nerve·Lior LowensteinKimberly Kenton
Nov 21, 2008·European Journal of Pain : EJP·Claudia Maria Santos AgostinhoChristoph Maier
Sep 11, 2009·British Journal of Clinical Pharmacology·Camilla StaahlAsbjørn Mohr Drewes
May 19, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Victoria HeldestadErik Nordh
Aug 4, 2011·Journal of Pain Research·Meryl J AlappattuMichael E Robinson
Sep 6, 2011·Nature Reviews. Drug Discovery·Florian PrinzKhusru Asadullah
Jun 23, 2012·Pharmacological Reviews·Anne Estrup OlesenAsbjørn Mohr Drewes
Jul 10, 2012·Journal of Rehabilitation Research and Development·Niamh A MoloneyCatherine M Doody
Oct 2, 2012·Nature Reviews. Drug Discovery·Ian S PeersChris Harbron
Oct 23, 2012·British Journal of Pharmacology·Bruno Georg Oertel, Jörn Lötsch
Jan 2, 2015·Circulation Research·C Glenn Begley, John P A Ioannidis
Sep 1, 2015·Science·UNKNOWN Open Science Collaboration
Apr 14, 2016·Pharmacology Research & Perspectives·Ryan Patel, Anthony H Dickenson
Apr 27, 2016·Critical Reviews in Biochemistry and Molecular Biology·James Offord, Lori L Isom
May 6, 2016·Expert Opinion on Drug Metabolism & Toxicology·János TajtiLászló Vécsei
May 21, 2016·British Journal of Clinical Pharmacology·Guido van AmerongenJustin L Hay

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Methods Mentioned

BETA
sedation
pregnancy test

Clinical Trials Mentioned

NCT02238717
NCT02260947
NCT02349607

Software Mentioned

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