Reproducibility of Dietary Biomarkers in a Multiethnic Asian Population

Molecular Nutrition & Food Research
Clare WhittonRob M van Dam

Abstract

Dietary biomarkers allow for study of diet and disease risk relationships, but a key requirement is that these biomarkers are reproducible and reflect long-term diet. This study assesses reproducibility of selected dietary biomarkers in a multi-ethnic Asian population, and quantifies diet-disease relationship attenuation arising from use of a single biomarker measurement. Intra-class correlation coefficients (ICC) are used to evaluate the reproducibility of urinary isoflavone and enterolignan, total plasma fatty acid (FA), and serum carotenoid concentrations measured 4 months apart in adult Singapore residents (ethnic Chinese, n 59; Malay, n 46; Indian, n 56). Total carotenoid ICC is 0.75 (95% confidence interval (CI) 0.68, 0.81), ranging from 0.63 to 0.84 for individual carotenoids. FA ICC (median) is 0.74 (inter-quartile range 0.70-0.78). Total isoflavone ICC (95% CI) is 0.21 (0.06-0.35). Total enterolignan ICC is 0.42 (0.28, 0.54). Attenuation factors associated with a single time point measure ranged from 0.74 to 0.94 for carotenoids and FAs, and 0.42 to 0.70 for isoflavones and enterolignans. In a multi-ethnic Asian population, single measures of most serum carotenoids and plasma FAs likely represent habitual diet, whereas...Continue Reading

References

Jan 1, 1985·American Journal of Epidemiology·C T SemposC Gilligan
Dec 2, 1994·Journal of Chromatography. B, Biomedical Applications·A A Franke, L J Custer
Mar 4, 2003·The Journal of Nutrition·Johanna W Lampe
Jun 2, 2005·Journal of Exposure Analysis and Environmental Epidemiology·Liza Valentín-BlasiniDana B Barr
Jan 18, 2006·Cancer Causes & Control : CCC·Pamela L Horn-RossKenneth Jones
Nov 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Richard B HeathKeith N Frayn
Mar 22, 2007·The Journal of Nutrition·Sang-Ah LeeXiao Ou Shu
Feb 28, 2008·Epidemiology·Wael K Al-DelaimyUNKNOWN Women's Healthy Eating and Living (WHEL) Study Group
May 13, 2009·Molecular and Cellular Endocrinology·Christopher R Cederroth, Serge Nef
Oct 30, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gary E FraserHannelore Bennett
Mar 17, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·W-P KohC-N Ong
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joanne KotsopoulosA Heather Eliassen
Jun 6, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H R HarrisK B Michels
Mar 20, 2015·World Journal of Diabetes·Mohammad Talaei, An Pan
Jul 1, 2016·JAMA Internal Medicine·Liana C Del GobboUNKNOWN Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCe)
Jan 5, 2017·The American Journal of Clinical Nutrition·Qi SunWalter C Willett
Mar 30, 2017·The Proceedings of the Nutrition Society·Jayne V WoodsideMichelle C McKinley

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