Reproducibility of digital image analysis for measuring corneal haze after myopic photorefractive keratectomy

American Journal of Ophthalmology
M J MaldonadoJ L Menezo

Abstract

To evaluate the usefulness of digital image analysis for quantifying corneal haze by determining the reproducibility of its measurements at the corneal plane. In a prospective study, 20 randomly selected eyes that had undergone myopic photorefractive keratectomy were photographed focusing the slit beam on their anterior corneal surface. Each photograph was examined using computer image analysis techniques that detect the edge of the reticular pattern of the image. Quantification of the difference between two areas, treated and adjacent untreated cornea, each containing 3,750 pixels with a resolution of 256 gray levels, was performed. Intra-analyzer variation was determined by evaluating the photographs obtained by two analyzers under standard conditions on four separate visits. Interanalyzer variation was calculated using one measurement and the mean of the four measurements. The pooled standard deviation of the measurements for the analyzers was 0.63 and 0.62 gray levels (coefficient of variation, 4.1% and 3.3%). An association between less severe haze measurements and higher reproducibility scores was found (r = .42; P = .007). The mean interanalyzer variation was smaller for the average of four measurements, 0.55 +/- 0.37 gr...Continue Reading

References

Feb 1, 1990·Ophthalmology·C J PavlinF S Foster
May 1, 1990·Archives of Ophthalmology·F E FantesM Savoldelli
Jul 1, 1995·Journal of Cataract and Refractive Surgery·J L MenezoA Cisneros

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Citations

Aug 31, 1999·Survey of Ophthalmology·H K Li
Dec 2, 2011·Japanese Journal of Ophthalmology·Tsuyoshi YonedaAtsuki Fukushima
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·James S Wolffsohn, Christine Purslow
May 3, 2002·Ophthalmology·Miguel J Maldonado
Nov 20, 1998·American Journal of Ophthalmology·B SeitzP J McDonnell
Jan 27, 2007·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Luigina SorbaraDesmond Fonn
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Clare O'Donnell, James S Wolffsohn
Jan 25, 2017·Current Eye Research·Mohd Radzi HilmiTengku Mohd Tengku Sembok
Mar 12, 2008·Expert Review of Medical Devices·Miguel J MaldonadoDavid P Piñero
Jun 19, 2001·Annals of Medicine·H LamminenK Ruohonen
Jun 13, 2019·Seminars in Ophthalmology·Thomas H DohlmanReza Dana
Apr 24, 2003·Acta Ophthalmologica Scandinavica. Supplement·Torben Møller-Pedersen
May 20, 2003·Acta Ophthalmologica Scandinavica·Heikki LamminenHannu Uusitalo

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