Reproducibility of flow mediated skin fluorescence to assess microvascular function

Microvascular Research
Marcin HellmannJ L Cracowski

Abstract

Recent technical developments enable skin fluorescence to be quantified in vivo in humans. The present study aimed at determining whether flow mediated skin fluorescence was reproducible, sensitive to changes within an individual, and if it could differ between patients with coronary artery disease and healthy volunteers. First, forearm flow mediated skin fluorescence recorded during and after brachial artery occlusion was assessed following successive forearm occlusion periods (1, 2, 3 and 5min) and expressed as ischemic and hyperemic responses (as % of baseline). Secondly, 3min flow mediated skin fluorescence was assessed before and after 10min local cooling to 15°C. In a third protocol, the inter-day reproducibility of ischemic and hyperemic responses to 3min occlusion was tested at an interval of 7days, and compared between healthy controls and patients with coronary artery disease (CAD). In the first protocol, we observed a time dependent increase in the ischemic and hyperemic responses to occlusion. Next, we observed a lower hyperemic response after local cooling (9.8±4.2 versus 17.8±2.5% respectively, P<0.001), while in contrast, the ischemic response was higher and exhibited greater variability (23±15 versus 11.8±6.4%; ...Continue Reading

Citations

Dec 20, 2019·Journal of Diabetes Science and Technology·Joanna KatarzynskaJerzy Gebicki
Jan 14, 2020·BioMed Research International·Jaroslaw BogaczewiczAnna Wozniacka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Dementia and Geriatric Cognitive Disorders
B M McGleenonG D Johnston
Clinical Hemorheology and Microcirculation
Ana MihorHelena Lenasi
International Journal of Sports Medicine
J BrunnekreefD H J Thijssen
© 2022 Meta ULC. All rights reserved