Reproducibility of Intra- and Inter-scanner Measurements of Liver Fat Using Complex Confounder-corrected Chemical Shift Encoded MRI at 3.0 Tesla

Scientific Reports
Bing WuXinhuai Wu

Abstract

The purpose of this study was to prospectively evaluate the reproducibility of the proton density fat-fraction (PDFF) of the liver using the IDEAL algorithm, a quantitative confounder-corrected chemical-shift-encoded MRI method. Data were obtained from 15 volunteers on four different days. The first and the third examinations were conducted on scanner one with one-week intervals, while the second and the fourth tests were performed on scanner two with same time interval. For each test, two MR scans were performed, one before and one after a meal. Regions-of-interest measurements were manually calculated to estimate the PDFF in the right and left lobes on the PDFF images. Reproducibility was measured using the intra-class correlation coefficient (ICC). The ICCs of the PDFF in the right and left lobes were 0.935 and 0.878, respectively. The intra-scanner ICCs of the right lobe before and after a meal or at a one-week interval were 0.924 and 0.953, respectively. The inter-scanner ICCs of PDFF the next day and at a one-week interval were 0.920 and 0.864, respectively. The PDFF of liver derived from IDEAL demonstrated high intra- and inter-scanner measurement reproducibility. The PDFF of the right lobe before a meal was more reprodu...Continue Reading

References

Aug 11, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott B ReederNorbert J Pelc
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chia-Ying LiuScott B Reeder
Sep 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Huanzhou YuScott B Reeder
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Huanzhou YuScott B Reeder
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Jan 8, 2011·Radiology·Takeshi YokooClaude B Sirlin
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Jul 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Geraldine H KangClaude B Sirlin

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Citations

Apr 14, 2019·Journal of Magnetic Resonance Imaging : JMRI·Frederic Carsten SchmeelGuido Matthias Kukuk
Jun 7, 2019·Journal of Magnetic Resonance Imaging : JMRI·Timothy J ColganScott B Reeder
Sep 12, 2017·Radiology·Takeshi YokooUNKNOWN RSNA-QIBA PDFF Biomarker Committee
Aug 6, 2020·Nutrients·Brittanie KilchoerLia Bally
Jan 20, 2021·Radiology·Houchun H HuUNKNOWN RSNA Quantitative Imaging Biomarkers Alliance PDFF Biomarker Committee
Jan 1, 2021·Current Developments in Nutrition·Maggie S BurhansMario Kratz

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Software Mentioned

IDEAL IQ
SPSS
IDEAL
MacOS X
OsiriX

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