Reproducibility of left ventricular volume and ejection fraction measurements in rat using pinhole gated SPECT

European Journal of Nuclear Medicine and Molecular Imaging
Christian VanhovePhilippe R Franken

Abstract

The aim of this study was to investigate the intra-individual reproducibility of left ventricular volume and ejection fraction measurements in living rat using pinhole gated single-photon emission computed tomography (SPECT). Eight normal male Wistar rats underwent four pinhole gated SPECT acquisitions over a 1-month period. Two pinhole gated myocardial perfusion SPECT studies were acquired at a 1-week interval after injecting the animals with 439+/-52 MBq of (99m)Tc-sestamibi. Subsequently, 1 week after the perfusion studies, two pinhole gated blood pool SPECT studies were acquired at a 1-week interval after in vivo labelling of the red blood cells using 520+/-49 MBq of (99m)Tc-pertechnetate. Pinhole gated SPECT acquisitions were done on a single-head gamma camera equipped with a pinhole collimator with a 3-mm opening and 165-mm focal length. Parameters of acquisition were as follows: 44 mm radius of rotation, 360 degrees rotation using a circular orbit, 64 projections, 64x64 matrix, gating using 16 time frames and 22-min acquisition time. The projection data were reconstructed with a modified version of OSEM taking into account the pinhole geometry and incorporating a prior assumption about the temporal properties of gated SP...Continue Reading

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Citations

Jan 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Reza GolestaniRiemer H J A Slart
Jun 9, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tony Lahoutte
May 24, 2011·International Journal of Molecular Imaging·Magdy M KhalilWilly Gsell
Apr 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Benjamin M W Tsui, Dara L Kraitchman
Jan 21, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Hein J VerberneBerthe L F van Eck-Smit
May 22, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robert A de KempErik L Ritman
Mar 31, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nguyen TranPierre-Yves Marie
Feb 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Christian VanhoveTony Lahoutte
Dec 21, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrei TodicaM Hacker
Aug 29, 2006·Current Problems in Cardiology·Raymond R Russell, Barry L Zaret
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