Reproducibility of multi-shell diffusion tractography on traveling subjects: A multicenter study prospective

Magnetic Resonance Imaging
Qiqi TongJianhui Zhong

Abstract

Reproducibility of multicenter diffusion magnetic resonance imaging has drawn more attention recently due to rapidly increasing need for large-size brain imaging studies. Advanced multi-shell diffusion models are recommended for their potentials to provide variety of physio-pathological information. While previous studies have investigated the consistency of single-shell diffusion acquisition from various hardware and protocols, a well-controlled study with multi-shell acquisition would be necessary to understand the inherent factors of reproducibility from new complexity of such acquisition protocol. In this study, three traveling subjects were scanned at eight imaging centers equipped with the same type of scanners using the same multi-shell diffusion imaging protocol. Track density imaging and structure connectomes were investigated in local-scale distribution and in distal-scale connectivity, respectively. With evaluations of the coefficient of variation and the intra-class correlation coefficient, our results indicated: 1) similar to single-shell schemes, the intra-center reproducibility of multi-shell is higher than inter-center; 2) multi-shell schemes produce higher reproducibility and precision among centers compared to...Continue Reading

Citations

Sep 2, 2020·Chemical Society Reviews·Lulu LiJinlong Gong
May 22, 2020·Frontiers in Neuroscience·Maíra Siqueira PintoJan Sijbers
Oct 13, 2020·NeuroImage·Kristin KollerDerek K Jones
Jun 29, 2021·Frontiers in Aging Neuroscience·Zhanxiong WuUNKNOWN and The Alzheimer’s Disease Neuroimaging Initiative

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