Reproducibility of native T1 mapping for renal tissue characterization at 3T

Journal of Magnetic Resonance Imaging : JMRI
Ilona A DekkersHildo J Lamb

Abstract

Advanced renal disease is characterized by adverse changes in renal structure; however, noninvasive techniques to diagnose and monitor these changes are currently lacking. To evaluate the reproducibility of native T1 mapping for renal tissue characterization. Reproducibility study. Fifteen healthy volunteers (mean age 31 years, range 19-63 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51-69 years). 3T, modified Look-Locker imaging (MOLLI) 5(3)3. Intra- and interexamination reproducibility of voxel-based T1 relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients. Reproducibility was evaluated using Bland-Altman and intraclass correlation coefficients (ICCs). Intra- and interexamination reproducibility of renal native T1 mapping showed good-strong ICCs (0.83-0.89) for renal cortex and medulla, and moderate-good ICCs (0.62-0.81) for cortex-medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra- and interexamination limits of agreement were respectively (-124 msec, + 82 msec) and (-134 msec, + 98 msec) for renal cortex and (-138 msec, + 107 msec) and (-118 msec, + 151 msec) for medulla. Overall T1 values for rena...Continue Reading

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Citations

Apr 17, 2020·Journal of Magnetic Resonance Imaging : JMRI·Anneloes de BoerTim Leiner
Feb 1, 2021·Medical Image Analysis·Israa AlnazerChristine Fernandez-Maloigne
Feb 23, 2021·Drug Discovery Today·Anjali SrivastavaShrikant R Mulay
Jun 9, 2021·Radiology·Christina J MacAskillYong Chen
Jul 23, 2021·Journal of Magnetic Resonance Imaging : JMRI·Jianqin JiangShaowei Hao
Aug 28, 2021·Journal of Personalized Medicine·Ling LinHildo J Lamb

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