Reproducibility of odor maps by fMRI in rodents

NeuroImage
James SchaferF Hyder

Abstract

The interactions of volatile odorants with the approximately 1000 types of olfactory receptor neurons in the olfactory mucosa are represented in the olfactory bulb by glomerular spatial activity maps. If these spatial maps underlie the perceptual identification of odorants then, for a given organism, they must be both specific and reproducible. However, this intra-organism reproducibility need not be present between organisms because genetic and developmental studies of olfactory bulb wiring suggest that there is substantial variation between the glomerular arrangements of closely related organisms and even between the two bulbs in a given animal. The ability of functional MRI (fMRI) to record responses of the entire rodent olfactory bulb repeatedly within the same subject has made it possible to assess the reproducibility of odor-induced spatial activity maps both within and between subjects exposed to equivalent stimuli. For a range of odorants, representing multiple chemical classes, a level of fMRI reproducibility (at 7.0 T and 9.4 T) comparable or superior to other cortical regions was demonstrated. While the responses of different bulbs to the same odorant could be localized within the same broad regions of the glomerular...Continue Reading

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Citations

Jun 17, 2008·Journal of Chemical Ecology·A Gelperin
Apr 26, 2008·NMR in Biomedicine·Basavaraju G SanganahalliFahmeed Hyder
May 8, 2007·The Journal of Comparative Neurology·Brett A Johnson, Michael Leon
Dec 18, 2010·The Journal of Comparative Neurology·Rachel B KayPeter C Brunjes
Jan 15, 2014·NeuroImage·Alexander John Poplawsky, Seong-Gi Kim
Oct 5, 2007·Journal of Neurophysiology·Christopher I Moore, Rosa Cao
Feb 23, 2020·NeuroImage·Basavaraju G SanganahalliFahmeed Hyder
Sep 1, 2021·Seminars in Cell & Developmental Biology·Sue KulasonAkira Sawa

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