Reproducibility of phase rotation stimulated echo acquisition mode at 3T in schizophrenia: Emphasis on glutamine

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Juan R BustilloS Andrea Wijtenburg

Abstract

To determine the reproducibility and reliability of glutamine (Gln), measured with a very short echo time phase rotation stimulated echo acquisition mode (VTE-PR STEAM) sequence at 3T, in subjects with schizophrenia. Seven subjects with schizophrenia were scanned twice with VTE-PR STEAM in a Siemens 3T TIM Trio scanner with a 32-channel head coil. Spectroscopic data were collected from two voxels in gray matter, one in the dorsal anterior cingulate and the other in the medial occipital cortex. Reproducibility was assessed using coefficients of variation (CVs) and reliability with standard error of measurement and intraclass correlations (ICCs). Phantoms containing increasing concentrations of Gln in a physiologic solution of other neurometabolites with overlapping resonances were scanned to assess the validity of spectral Gln measurement. Very good reliability and reproducibility for Gln in both regions of interest were supported by CVs of ≤10.0% and ICCs of ≥0.6, respectively. Phantom studies documented a robust correspondence between known Gln concentrations and VTE-PR STEAM measurements of this metabolite (R(2)  = 0.988). The VTE-PR STEAM approach at 3T permits the longitudinal assessment of Gln and other (1) H MR spectrosco...Continue Reading

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Citations

Oct 17, 2017·Schizophrenia Bulletin·Joshua ChiappelliLiyi Elliot Hong
Oct 4, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Osnat Volovyk, Assaf Tal
Jun 19, 2018·Schizophrenia Bulletin·Dinesh K ShuklaLaura M Rowland
Sep 6, 2019·Psychopharmacology·Alice Egerton
Aug 27, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Andrea WijtenburgLaura M Rowland
Jul 5, 2017·Frontiers in Psychiatry·Laura M RowlandDeanna L Kelly
Apr 20, 2021·Frontiers in Psychiatry·S Andrea WijtenburgLaura M Rowland
Jan 1, 2015·Neuropsychiatric Electrophysiology·Robert J ThomaPaul G Mullins

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