Reproducibility of serum pituitary hormones in women.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Alan A ArslanAnna Lokshin

Abstract

Endogenous pituitary hormones are commonly used in clinical and epidemiologic studies and some of them are thought to influence the risk of several diseases in women. In most studies, endogenous levels of pituitary hormones are usually assessed at a single point in time, assuming that this single measurement represents the long-term biomarker status of the individual. Such an assumption is rarely tested and may not always be valid. This study examined the reproducibility of the following pituitary hormones: adrenocorticotropic hormone (ACTH), growth hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and prolactin, measured using the Luminex xMap method in sera of healthy premenopausal and postmenopausal women. The study included 30 premenopausal women with three yearly samples and 35 postmenopausal women with two repeated yearly samples randomly selected from an existing prospective cohort. Analysis of intraclass correlation coefficients suggested higher reproducibility in postmenopausal women compared with premenopausal women for the following hormones: FSH (0.72 and 0.37, respectively), LH (0.83 and 0.44, respectively), and growth hormone (0.60 and 0.35, respectively). Th...Continue Reading

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Citations

Feb 5, 2013·Cancer Causes & Control : CCC·Tess V ClendenenAnne Zeleniuch-Jacquotte
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zoya YurkovetskyAnna E Lokshin
Feb 18, 2010·Biologics : Targets & Therapy·Ahmed Gibreel, Siladitya Bhattacharya
Apr 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K TikkR Kaaks
May 16, 2014·Journal of the National Cancer Institute·Sabina RinaldiSilvia Franceschi
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Jul 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K TikkR Kaaks

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