Reproducibility of swollen sinuses in broilers by experimental infection with avian metapneumovirus subtypes A and B of turkey origin and their comparative pathogenesis

Avian Pathology : Journal of the W.V.P.A
Ye Htut AungSilke Rautenschlein

Abstract

Swollen head syndrome (SHS) associated with avian metapneumovirus (aMPV) subtype A or subtype B in broilers and broiler breeders has been reported worldwide. Data about pathogenesis of aMPV subtypes A and B in broilers are scarce. It has been difficult to reproduce swollen sinuses in chickens with aMPV under experimental conditions. In the field, SHS in broilers is suspected to be induced by combined infections with different respiratory pathogens. The objectives of the present study were to compare the pathogenesis of subtypes A and B aMPV in commercial broilers and to investigate the reproducibility of clinical disease. In two repeat experiments, commercial broilers free of aMPV maternal antibodies were inoculated with aMPV subtypes A and B of turkey origin. The clinical signs such as depression, coughing, nasal exudates, and frothy eyes appeared at 4 days post inoculation, followed by swelling of periorbital sinuses at 5 days post inoculation. Higher numbers of broilers showed clinical signs in subtype-B-inoculated compared with subtype-A-inoculated groups. Seroconversion to aMPV was detectable from 10 to 11 days post inoculation. The appearance of serum aMPV enzyme-linked immunosorbent assay antibodies and the clearance of ...Continue Reading

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Citations

Dec 25, 2010·Veterinary Immunology and Immunopathology·Silke RautenschleinChristine Haase
Sep 15, 2015·Avian Pathology : Journal of the W.V.P.A·Sandra HartmannSilke Rautenschlein
Jan 21, 2014·Avian Pathology : Journal of the W.V.P.A·Faez AwadKannan Ganapathy
Nov 1, 2016·Journal of Virology·Bingling YunXiaomei Wang

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
MDA
ELISA

Software Mentioned

SPSS

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