DOI: 10.1101/494765Dec 13, 2018Paper

Reproducibility of the correlative triad among aging, dopamine D2-like receptor availability, and cognition

BioRxiv : the Preprint Server for Biology
Eric J JuarezGregory R Samanez-Larkin


The evidence that dopamine function mediates the association between aging and cognition is one of the most cited findings in the cognitive neuroscience of aging. However, few and relatively small studies have directly examined these associations. Here we examined correlations among adult age, dopamine D2-like receptor (D2R) availability, and cognition in two cross-sectional studies of healthy human adults. Participants completed a short cognitive test battery and, on a separate day, a PET scan with either the high-affinity D2R tracer [18F]Fallypride (Study 1) or [11C]FLB457 (Study 2). Digit span, a measure of short-term memory maintenance and working memory, was the only cognitive test for which dopamine D2R availability partially mediated the age effect on cognition. In Study 1, age was negatively correlated with digit span. Striatal D2R availability was positively correlated with digit span controlling for age. The age effect on digit span was smaller when controlling for striatal D2R availability. Although other cognitive measures used here have individually been associated with age and D2R availability in prior studies, we found no consistent evidence for significant associations between low D2R availability and low cognit...Continue Reading

Related Concepts

Base Sequence
Cross-Sectional Studies
Memory, Short-Term
Positron-Emission Tomography
Dopamine D2 Receptor

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