PMID: 8980159Nov 1, 1996Paper

Reproducibility of the growth hormone response to stimulation with growth hormone-releasing hormone plus arginine during lifespan

European Journal of Endocrinology
M R ValettoE Ghigo

Abstract

The reliability and reproducibility of provocative stimuli of growth hormone (GH) secretion in the diagnosis of GH deficiency are still controversial both in childhood and in adulthood. The combined administration of GH-releasing hormone (GHRH) and arginine (ARG), which likely acts via inhibition of hypothalamic somatostatin release, is one of the most potent stimuli known so far and has been proposed recently as the best test to explore the maximal somatotrope capacity of somatotrope cells. However, it is well known that, usually, provocative stimuli of GH secretion suffer from poor reproducibility and that of the GHRH + ARG test has still to be verified. We aimed to verify the between- and within-subject variability of the GH response to the GHRH + ARG test in normal subjects during their lifespan as well as in hypopituitaric patients with GH deficiency (GHD). In 10 normal children (C: six male and four female, age 12.3 +/- 0.9 years, body mass index (BMI) = 16.6 +/- 0.7 kg/m2, pubertal stages I-III), 18 normal young adults (Y: ten male and eight female, age 31.1 +/- 1.3 years, BMI = 21.4 +/- 0.4 kg/m2), 12 normal elderly subjects (E: two male and ten female, age 74.4 +/- 1.8 years, BMI= 22.6 +/- 0.6 kg/m2) and 15 panhypopitu...Continue Reading

Citations

Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·S Stavrou, D L Kleinberg
May 9, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G CorneliG Aimaretti
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S FiskerJ S Christiansen
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E GhigoF Camanni
Jul 16, 2004·Journal of Neurotrauma·Marta BondanelliEttore C I degli Uberti
Apr 25, 2012·European Journal of Endocrinology·O AjalaD E Flanagan
Jul 20, 2005·Treatments in Endocrinology·Andrew A Toogood
Apr 14, 2006·Journal of Endocrinological Investigation·F Camanni
Nov 5, 1998·Journal of Endocrinological Investigation·G AimarettiE Ghigo
Mar 30, 2007·Journal of Endocrinological Investigation·L de SanctisC de Sanctis
May 28, 2002·Journal of Endocrinological Investigation·M GasperiE Martino
Mar 11, 2004·Journal of Endocrinological Investigation·F L ConceiçãoM Vaisman
Feb 15, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Laura DreismannGerhard Binder
Mar 20, 1999·Baillière's Clinical Endocrinology and Metabolism·E GhigoF Camanni
Sep 4, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E GhigoG Corneli
Feb 10, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kevin C J YuenDavid M Cook
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D M Cook
Jul 18, 2001·Frontiers in Neuroendocrinology·F L ConceiçãoJ S Christiansen
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P C SizonenkoZ Laron
Apr 20, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H C HoeckP Laurberg
Mar 29, 2007·Hormone Research·K Kaushal, S M Shalet
Jan 27, 2019·International Journal of Environmental Research and Public Health·Laura PentaSusanna Esposito
May 7, 1998·Endocrine Reviews·S M ShaletB M Brennan
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Beverly M K BillerMark L Hartman
Dec 29, 2006·The Journal of Clinical Endocrinology and Metabolism·S SiyambalapitiyaR J Ross
Mar 6, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Jennifer L Copeland
Sep 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Annamaria ColaoGaetano Lombardi
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Polyxeni KoutkiaSteven Grinspoon
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·G AimarettiE Ghigo
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Giovanna MantovaniAnna Spada
May 9, 2000·Journal of Endocrinological Investigation·J BelloneE Ghigo
Jul 21, 2010·Deutsches Ärzteblatt International·Stephan PetersennMichael Buchfelder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.