Reproducibility of the nicotine metabolite ratio in cigarette smokers.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Gideon St HelenNeal L Benowitz

Abstract

The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze (i) the stability of NMR in plasma, saliva, and blood in various storage conditions, (ii) the relationship between NMRs derived from blood, plasma, saliva, and urine, and (iii) the reproducibility of plasma NMR in ad libitum cigarette smokers. We analyzed data from four clinical studies. In studies 1 and 2, we assessed NMR stability in saliva and plasma samples at room temperature (~22°C) over 14 days and in blood at 4°C for up to 72 hours. In studies 2 and 3, we used Bland-Altman analysis to assess agreement between blood, plasma, saliva, and urine NMRs. In study 4, plasma NMR was measured on six occasions over 44 weeks in 43 ad libitum smokers. Reliability coefficients for stability tests of NMR in plasma and saliva at room temperature were 0.97 and 0.98, respectively, and 0.92 for blood at 4°C. Blood NMR agreed consistently with saliva and plasma NMRs but showed more variability in relation to urine NMR. The reliability coefficient for repeated plasma NMR measurements in smokers was 0.85. The NMR is stable in blood, plasma, and saliva at the conditions tested. Blood,...Continue Reading

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Citations

May 16, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Gideon St HelenNeal L Benowitz
Oct 5, 2013·Harm Reduction Journal·Riccardo PolosaCirino Raciti
May 3, 2014·PloS One·Qian XiaoJoshua N Sampson
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Nov 7, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Glenn A Jacobson, Stuart G Ferguson
Jun 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Meghan J ChenowethRachel F Tyndale
Apr 22, 2015·CNS Drugs·Michael MamounArthur L Brody
May 23, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Pebbles FaganEric T Moolchan
Mar 23, 2007·European Journal of Pharmacology·Dariusz PogockiElzbieta Wałajtys-Rode
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May 27, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Julie-Anne TannerRachel F Tyndale
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Sep 23, 2018·Clinical Pharmacology and Therapeutics·Evangelia LiakoniNeal L Benowitz
Jan 19, 2019·Journal of the National Cancer Institute·Nicole L NollenJasjit S Ahluwalia
Mar 11, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob
Apr 17, 2013·Clinical Pharmacology and Therapeutics·K J BoughS Amur
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Oct 2, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzMegan E Piper
Sep 11, 2019·Addiction·Annie R PengRachel F Tyndale
Apr 19, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Henry R KranzlerRobert Schnoll
Nov 15, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Evangelia LiakoniNeal L Benowitz
Sep 12, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jiyeon YangYoungwook Lim
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