PMID: 11606012Oct 19, 2001Paper

Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease

European Journal of Applied Physiology
L Puente-MaestuB J Whipp

Abstract

To be clinically useful as indices reflective of altered physiological function consequent to interventions in patients with chronic obstructive pulmonary disease (COPD), the time constant (tau) and steady-state amplitude of the kinetic responses for oxygen uptake (VO2) carbon dioxide output (VCO2) ventilation (VE) and heart rate (HR) have to be appropriately differentiable and reproducible. We therefore assessed the reproducibility of tau and steady state amplitude values in 41 patients with severe COPD [mean (SD)] [forced expiratory volume in 1 s = 41 (7)% predicted], aged 64 (5) years. Of the total, 6 of the patients (15%) did not produce breath-by-breath data of sufficient quality to warrant kinetic analysis. The remaining 35 patients completed two moderate-intensity 10 min square-wave exercise tests separated by 2 h, both before and after an endurance training programme. Tests were conducted on an electromagnetically-braked cycle ergometer at an exercise intensity corresponding to 80% of the estimated lactate threshold (thetaLa) or 50% of peak oxygen uptake if thetaLa was insufficiently differentiable. Breath-by-breath measurements of VO2, VCO2, VE and HR were averaged into 10 s bins and the on-transient response kinetics ...Continue Reading

Citations

Jul 26, 2012·European Journal of Applied Physiology·Matthew D SpencerDonald H Paterson
Aug 24, 2006·Journal of Cardiopulmonary Rehabilitation·Ross Arena, Mary Ann Peberdy
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Isabel BlancoJoan Albert Barberà
Nov 3, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Audrey Borghi-SilvaDirceu Costa
Mar 23, 2011·Respiratory Physiology & Neurobiology·Simon MarwoodPeter Calverley
Nov 26, 2003·Archives of Physical Medicine and Rehabilitation·Yagesh BhambhaniMamdouh Farag
Mar 1, 2012·Respiratory Physiology & Neurobiology·Aurélien BringardStéphane Perrey
Jul 28, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andiara WolpatGaspar R Chiappa
Jan 17, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Paulo de Tarso MüllerGaspar Rogério Chiappa
Feb 24, 2015·The Cochrane Database of Systematic Reviews·Bernard McCarthyYves Lacasse
Jun 23, 2020·Work : a Journal of Prevention, Assessment, and Rehabilitation·Todd E DavenportJ Mark Van Ness
May 8, 2018·European Journal of Applied Physiology·Susan A Ward

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