Reproducibility of the Structural Brain Connectome Derived from Diffusion Tensor Imaging

PloS One
Leonardo BonilhaNiels K Focke

Abstract

Disruptions of brain anatomical connectivity are believed to play a central role in several neurological and psychiatric illnesses. The structural brain connectome is typically derived from diffusion tensor imaging (DTI), which may be influenced by methodological factors related to signal processing, MRI scanners and biophysical properties of neuroanatomical regions. In this study, we evaluated how these variables affect the reproducibility of the structural connectome. Twenty healthy adults underwent 3 MRI scanning sessions (twice in the same MRI scanner and a third time in a different scanner unit) within a short period of time. The scanning sessions included similar T1 weighted and DTI sequences. Deterministic or probabilistic tractography was performed to assess link weight based on the number of fibers connecting gray matter regions of interest (ROI). Link weight and graph theory network measures were calculated and reproducibility was assessed through intra-class correlation coefficients, assuming each scanning session as a rater. Connectome reproducibility was higher with data from the same scanner. The probabilistic approach yielded larger reproducibility, while the individual variation in the number of tracked fibers f...Continue Reading

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Citations

Apr 1, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A GuptaJ S Labus
Jan 5, 2017·NeuroImage. Clinical·Sara LlufriuAlbert Saiz
Dec 15, 2015·PLoS Computational Biology·Frances HutchingsMarcus Kaiser
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May 20, 2020·Journal of Neural Engineering·Yusuf OsmanlıoğluRagini Verma
Apr 20, 2019·Frontiers in Neurology·Swathi Kiran, Cynthia K Thompson
Feb 26, 2019·Frontiers in Aging Neuroscience·Sebastian StraussMatthias Grothe
Oct 23, 2019·Network Neuroscience·Linda DouwCornelis J Stam
Sep 15, 2017·Scientific Reports·Cesar F Caiafa, Franco Pestilli

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Software Mentioned

FDT
probtrackx
BEDPOST
mriconvert
Invivo
Diffusion Toolkit
FMRIB Software Library ( FSL )
Diffusion Toolkit ( FDT )
Freesurfer
IPAT

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