Reproducibility of tricuspid regurgitant jet velocity measurements in children and young adults with sickle cell disease undergoing screening for pulmonary hypertension

American Journal of Hematology
Robert I LiemAlexis A Thompson

Abstract

The reproducibility of tricuspid regurgitant jet velocity (TRJV) measurements by Doppler echocardiography has not been subjected to systematic evaluation among individuals with sickle cell disease (SCD) undergoing screening for pulmonary hypertension. We examined sources of disagreement associated with peak TRJV in children and young adults with SCD. Peak TRJV was independently measured and interpreted a week apart by separate sonographers and readers, respectively, in 30 subjects (mean age, 15.8 ± 3.3 years) who provided 120 observations. We assessed intra-/inter-reader, intra-/inter-sonographer, sonographer-reader, and within subject agreement using Intraclass Correlation Coefficient (ICC) and Cohen's kappa (κ). Agreement was examined graphically using Bland-Altman plots. Although sonographers could estimate and measure peak TRJV in all subjects, readers designated tricuspid regurgitation nonquantifiable in 10-17% of their final interpretations. Intra-reader agreement was highest (ICC = 0.93 [95% CI 0.86, 0.97], P = 0.0001) and within subject agreement lowest (ICC = 0.36 [95% CI 0.02, 0.64], P = 0.021) for single TRJV measurements. Similarly, intra-reader agreement was highest (κ = 0.74 [95% CI 0.53, 0.95], P = 0.0001) and wi...Continue Reading

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Citations

Dec 20, 2011·Pediatric Blood & Cancer·Gregory J Kato
Jan 26, 2011·American Journal of Hematology·James R Eckman, Stephen H Embury
Nov 5, 2015·Circulation·Steven H AbmanUNKNOWN American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical C
Jul 30, 2020·The Western Journal of Emergency Medicine·Zachary W BinderJoseph R Pare
May 22, 2018·Pediatric Blood & Cancer·Tarek AlsaiedMichael D Taylor
Sep 23, 2019·Pediatric Cardiology·Kiona Y AllenShobha S Natarajan
Jun 10, 2011·Current Opinion in Cardiology

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