Reproducibility of urinary beta 2-microglobulin and cadmium excretion among residents in a cadmium-polluted area during a 3-year period

Toxicology Letters
K ArisawaH Saito

Abstract

To assess the measurement error by using single exposure measurement in epidemiologic studies, reproducibility of urinary beta 2-microglobulin and cadmium excretion was evaluated among persons exposed to environmental cadmium. We measured urinary beta 2-microglobulin concentrations in 47 subjects four times and urinary cadmium concentrations in 48 subjects twice, during a 3-year period. Between-person and within-person variance components of these variables were estimated using a random-effects one-way analysis of variance model. The intraclass correlation coefficient (ICC) for urinary beta 2-microglobulin concentration, when expressed as microg/g creatinine and microg/l, was 0.92 and 0.89, respectively. The ICC for standardized urinary cadmium concentration (expressed as microg/g creatinine) was 0.81, while it decreased to 0.33 without standardization. The findings suggest that single measurement of urinary beta 2-microglobulin and cadmium, when expressed as a function of creatinine, can reliably estimate average levels over at least a 3-year period. Standardization of concentration using urinary creatinine improved reproducibility especially for urinary cadmium excretion.

References

Aug 1, 1991·The Tohoku Journal of Experimental Medicine·K IwataA Nakano
Nov 1, 1989·British Journal of Industrial Medicine·H A RoelsM Oversteyns
May 1, 1988·Archives of Environmental Health·T KidoK Nogawa

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Citations

Oct 19, 2007·International Archives of Occupational and Environmental Health·Takashi YamagamiMasayuki Ikeda
Oct 28, 2016·Current Environmental Health Reports·Caterina Vacchi-SuzziJaymie R Meliker

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