Reproducible drug exanthema to terbinafine with characteristic distribution of baboon syndrome

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
J M WeissJ C Simon

Abstract

A 26 year old patient developed a fixed drug eruption located on his hands, inguinal and gluteal areas following oral treatment of onychomycosis with terbinafine. The rash showed the characteristic distribution of the "baboon-syndrome", so-named because of the red perianal region of the baboon. Although epicutaneous testing revealed no positive reaction, the rash could be induced in identical sites by oral administration of terbinafine. As the underlying pathomechanism for the "baboon-syndrome" a systemically induced allergic contact dermatitis has been suggested. In addition to the described substances, e.g. mercury, amoxicillin, ampicillin, heparin and nickel, this is the first report of "baboon syndrome" induced by terbinafine.

Citations

May 19, 2005·Contact Dermatitis·Alina Jankowska-KonsurEugeniusz Baran
Jan 20, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K BreuerT Werfel
Apr 8, 2011·American Journal of Clinical Dermatology·Gwenaëlle Allain-VeyracPascale Jolliet
Jun 11, 2011·Current Opinion in Allergy and Clinical Immunology·Sze-Chin Tan, Justina W-L Tan
May 7, 2016·International Journal of Dermatology·Shahbaz A JanjuaSadia Ammad
Sep 26, 2002·Pharmacoepidemiology and Drug Safety
Feb 26, 2004·Allergologia et immunopathologia·L Sánchez-MorillasA R Domínguez Lázaro
Aug 3, 2021·Clinical Reviews in Allergy & Immunology·Zhouxian PanJing Zhang

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