Reproducible epidemiologic research

American Journal of Epidemiology
Roger D PengScott L Zeger

Abstract

The replication of important findings by multiple independent investigators is fundamental to the accumulation of scientific evidence. Researchers in the biologic and physical sciences expect results to be replicated by independent data, analytical methods, laboratories, and instruments. Epidemiologic studies are commonly used to quantify small health effects of important, but subtle, risk factors, and replication is of critical importance where results can inform substantial policy decisions. However, because of the time, expense, and opportunism of many current epidemiologic studies, it is often impossible to fully replicate their findings. An attainable minimum standard is "reproducibility," which calls for data sets and software to be made available for verifying published findings and conducting alternative analyses. The authors outline a standard for reproducibility and evaluate the reproducibility of current epidemiologic research. They also propose methods for reproducible research and implement them by use of a case study in air pollution and health.

References

Jul 14, 1995·Science·G Taubes
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Aug 12, 2000·Epidemiologic Reviews·J M Samet
Jan 24, 1997·Science·Jocelyn Kaiser
Feb 2, 2002·JAMA : the Journal of the American Medical Association·Eric G CampbellDavid Blumenthal
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Oct 22, 2002·Science·Catherine A BallUNKNOWN Microarray Gene Expression Data (MGED) Society
Feb 1, 2003·Science·Kenneth A Colburn, Philip R S Johnson
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Michelle L BellFrancesca Dominici
Mar 5, 2005·American Journal of Epidemiology·Roger D PengJonathan M Samet
Mar 9, 2006·JAMA : the Journal of the American Medical Association·Francesca DominiciJonathan M Samet
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Markus RuschhauptUlrich Mansmann
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Robert Gentleman

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Citations

Nov 16, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S L SilvermanR Lindsay
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Jonathan M Samet
Jun 12, 2010·Biostatistics·Norman E Breslow
Jun 12, 2010·Biostatistics·Trish Groves
May 26, 2010·Biostatistics·Niels Keiding
Dec 15, 2010·Epidemiology·Antonio Gasparrini, Ben Armstrong
Dec 7, 2011·Science·Roger D Peng
May 21, 2013·BMC Genomics·Luigi MarchionniJeffrey T Leek
Jul 16, 2008·Emerging Themes in Epidemiology·Carl V PhillipsJay S Kaufman
Jun 23, 2009·Journal of the American Society of Nephrology : JASN·S Joseph Kim, John S Gill
Sep 22, 2010·Annals of Internal Medicine·Thomas R Fleming
Apr 16, 2014·Western Pacific Surveillance and Response Journal : WPSAR·Tom Hiatt, Nobuyuki Nishikiori
Aug 28, 2014·International Journal of Environmental Research and Public Health·Peter LercherJürg Thudium
Sep 4, 2015·Journal of Clinical Epidemiology·Koen B PouwelsEelko Hak
Jul 23, 2013·Journal of Substance Abuse Treatment·Beau AbarEdwin D Boudreaux
Feb 26, 2016·Royal Society Open Science·Richard D MoreyRolf A Zwaan
Jan 14, 2012·Trends in Ecology & Evolution·William K Michener, Matthew B Jones
Aug 24, 2007·The Lancet Infectious Diseases·Eric T Lofgren, Nina H Fefferman
Nov 19, 2013·Journal of Biomedical Informatics·Ida SimKnut M Wittkowski
Aug 19, 2009·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornTim Friede
Jan 22, 2013·Arthritis and Rheumatism·Mark J Soloski, Francis J Chrest
Jan 26, 2011·Journal of Advanced Nursing·Molly C DoughertySinead Keeney
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Aug 21, 2012·Statistics in Medicine·Douglas G AltmanKenneth F Schulz
Jun 20, 2014·Biometrical Journal. Biometrische Zeitschrift·Franz KoenigMartin Posch
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·David M EddyUNKNOWN ISPOR−SMDM Modeling Good Research Practices Task Force
Oct 22, 2014·PLoS Medicine·John P A Ioannidis
Jul 30, 2016·Frontiers in Psychology·Patrick Mair
Aug 12, 2016·Nature Communications·Karissa C ArthurBryan J Traynor
Sep 22, 2016·Experimental Gerontology·Tapan MehtaDavid B Allison
Jun 5, 2012·Critical Reviews in Toxicology·John F GamblePaolo Boffetta
Jul 31, 2016·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Prasad PatilJeffrey T Leek
Dec 17, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sean Hennessy, Charles E Leonard
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David M EddyUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Aug 24, 2017·American Journal of Epidemiology·Steven S Coughlin
Aug 24, 2017·American Journal of Epidemiology·Bryan E ShepherdCatherine C McGowan
Dec 16, 2017·American Journal of Respiratory and Critical Care Medicine·Corinne A KeetRoger D Peng
Dec 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone LaniniGiuseppe Ippolito
Nov 16, 2017·Journal of Cheminformatics·Andrius MerkysGiovanni Pizzi
Oct 5, 2017·Nature Reviews. Clinical Oncology·Philippe LambinSean Walsh

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