Reproducible model development in the cardiac electrophysiology Web Lab

Progress in Biophysics and Molecular Biology
Aidan C DalyG R Mirams

Abstract

The modelling of the electrophysiology of cardiac cells is one of the most mature areas of systems biology. This extended concentration of research effort brings with it new challenges, foremost among which is that of choosing which of these models is most suitable for addressing a particular scientific question. In a previous paper, we presented our initial work in developing an online resource for the characterisation and comparison of electrophysiological cell models in a wide range of experimental scenarios. In that work, we described how we had developed a novel protocol language that allowed us to separate the details of the mathematical model (the majority of cardiac cell models take the form of ordinary differential equations) from the experimental protocol being simulated. We developed a fully-open online repository (which we termed the Cardiac Electrophysiology Web Lab) which allows users to store and compare the results of applying the same experimental protocol to competing models. In the current paper we describe the most recent and planned extensions of this work, focused on supporting the process of model building from experimental data. We outline the necessary work to develop a machine-readable language to desc...Continue Reading

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Citations

Feb 23, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Dominic G WhittakerGary R Mirams
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Software Mentioned

WholeCellSimDB
Cardiac Electrophysiology Web
COPASI
CellML
CMA
Physiome
OpenCOR
KiSAO
ES
Web Lab

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Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

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