Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging

EJNMMI Research
Tong WangRobert A deKemp

Abstract

Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA1) graphical models to the standard one-tissue-compartment (1TC) model, including correction for partial-volume effects, in dynamic PET-CT studies of myocardial sympathetic innervation in the left ventricle (LV) using [11C]HED. Test and retest [11C]HED PET imaging (47 ± 22 days apart) was performed in 18 subjects with heart failure symptoms. Myocardial tissue volume of distribution (VT) was estimated using Logan and MA1 graphical methods and compared to the 1TC standard model values using intraclass correlation (ICC) and Bland-Altman analysis of the non-parametric reproducibility coefficient (NPC). A modeling start-time of t* = 5 min gave the best fit for both Logan and MA1 (R2 = 0.95) methods. Logan slightly underestimated VT relative to 1TC (p = 0.002), whereas MA1 did not (p = 0.96). Both the MA1 and Logan models exhibited good-to-excellent agreement with the 1TC (MA1-1TC ICC = 0.96; Logan-1TC ICC = 0.93) with no significant differences in NPC between the two comparisons (p = 0.92). All methods exhibited good-to-excelle...Continue Reading

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Citations

Dec 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Kai Yi WuRobert A deKemp
Apr 30, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jean Z WangRobert A deKemp
Jan 28, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jason G E ZeltLisa M Mielniczuk
Aug 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jean Z WangRobert A deKemp

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Clinical Trials Mentioned

NCT00756366

Software Mentioned

FlowQuant®
Logan
MATLAB
MA1
Excel
SPSS

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