PMID: 9169826Mar 15, 1997Paper

Reproducible rat model for comparing late rectal toxicity from different brachytherapy techniques

International Journal of Radiation Oncology, Biology, Physics
J R WhiteA Martinez

Abstract

Newer brachytherapy techniques, such as pulse-simulated low dose rate (PDR) and high dose rate (HDR) offer clinical and technical advantages over the conventional continuous low dose rate (CLDR) irradiation. The impact of these techniques on late normal tissue toxicity has remained largely undefined, with mathematical modeling and limited clinical experience providing some guidelines. We sought to develop a reproducible rat model for quantifying and comparing late rectal toxicity from different brachytherapy techniques. An intrarectal applicator has been designed and techniques have been developed to deliver clinically relevant doses of CLDR to allow comparison to PDR and HDR. Female Wistar rats are utilized. The endpoints assessed are rectal obstruction and a histological grading of late rectal injury. Analysis of 65 rats given either sham or single acute pulse irradiation has demonstrated the model to be reproducible and reliable in evaluating late rectal toxicity. The use of this rat model to compare late rectal injury from various doses, dose rates, and fractionation parameters utilized by CLDR, PDR, and HDR will provide another tool for safely implementing these techniques into the clinical setting.

References

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Citations

Apr 11, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M J Olofsen-van AchtM L van Velthuysen
Jul 1, 1997·International Journal of Radiation Oncology, Biology, Physics·E P ArmourA Martinez
Aug 6, 1998·The British Journal of Radiology·R G Dale, B Jones
Jan 21, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M NiedbalaG P Raaphorst
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Zvi SymonYehuda Chowers

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