Reproducible uniform coronary vasomotor tone with nitrocompounds: prerequisite of quantitative coronary angiographic trials

Catheterization and Cardiovascular Diagnosis
S JostP R Lichtlen

Abstract

In quantitative analysis of repeated coronary angiograms, a variable vasomotor tone of the epicardial coronary arteries may influence the accuracy of the results. Therefore, we evaluated the extent and reproducibility of coronary artery dilation with nitrocompounds. In 32 patients with coronary artery disease, the vasodilatory response of angiographically normal coronary segments to different nitrocompounds was analyzed with the computer-assisted contour detection system CAAS. Twenty patients received 5 mg or 10 mg of isosorbide dinitrate sublingually. After 10 to 15 min, a maximal diameter increase was measured with an average of 16 +/- 11% (5 mg: P less than 0.01) and 28 +/- 13% (10 mg: P less than 0.001) from control. Another 12 patients received 0.025 mg per kg body weight of SIN-1, the active metabolite of molsidomine, as an intravenous infusion over 5 min. A comparable maximal dilation (29 +/- 5%; P less than 0.001) occurred after 10 to 15 min and could not be enhanced further with 0.8 mg nitroglycerin administered sublingually (28 +/- 7%; n.s.). One hour after square root of Sin-1, coronary dilation was still 24 +/- 8% (P less than 0.001 compared with control), and 0.8 mg of nitroglycerin sublingually reestablished the p...Continue Reading

References

Jan 1, 1979·The American Journal of Cardiology·R L FeldmanC R Conti
Oct 1, 1988·Circulation Research·B Tesfamariam, R A Cohen
Nov 1, 1989·European Heart Journal·S JostP R Lichtlen
Oct 1, 1987·Circulation·E O Feigl
Sep 24, 1987·The New England Journal of Medicine·D C MayL D Hillis
Nov 1, 1986·The American Journal of Cardiology·J M IsnerR H Clarke
Mar 1, 1985·American Heart Journal·J SobolskiS Degre
Mar 28, 1985·The New England Journal of Medicine·A C ArntzeniusE A van der Velde
Sep 1, 1984·International Journal of Cardiology·J M Isner, D N Salem

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Citations

Jan 1, 1997·Cardiovascular and Interventional Radiology·S JostP R Lichtlen
May 1, 1993·Journal of the American College of Cardiology·S JostP R Lichtlen
Nov 25, 2000·Journal of the American College of Cardiology·D J Hildick-Smith, L M Shapiro
May 1, 1992·European Journal of Epidemiology·S JostP Lichtlen
Jul 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D J Hildick-Smith, L M Shapiro

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