PMID: 8950311Jan 1, 1996Paper

Reproduction and development in Drosophila are dependent upon catecholamines

Life Sciences
Robert G PendletonRalph Hillman

Abstract

Drosophila melanogaster, maintained on culture media containing alpha-methyl-p-tyrosine (alpha-MT) at millimolar levels for 7 days, fail to produce viable progeny. Lesser concentrations delay development. This effect of alpha-MT, an inhibitor of tyrosine hydroxylase (TH), is partially reversible by co-administration of L-dihydroxyphenylalanine, the product of TH. Potent inhibitors of other steps in the pathway for catecholamine biosynthesis are inactive except for a partial effect with dopamine B-hydroxylase inhibition. the effect of alpha-MT is due to a combination of ovulation suppression coupled with decreases in embryonic and larval viability. Effects similar to those of alpha-MT are found with millimolar levels of reserpine, prazosin and to a lesser extent, rauwolscine. No significant effects are found with propranolol, chlorpromazine, sulpiride and SK&F 83566. Mutant alleles of the gene coding for TH are known to be lethal at the embryonic stage when homozygous in both Drosophila and mice. Taken together, these results indicate that in addition to their established roles in the nervous system catecholamines function in animal development via an action mediated through alpha-adrenoceptors.

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Citations

Jan 15, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Katherine G Anitole-Misleh, Ken M Brown
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark G HearnAlan S Kopin
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Arati A InamdarJoan Wennstrom Bennett
Dec 10, 2014·ELife·Sofía Lavista-LlanosBill S Hansson
Sep 3, 2008·Journal of Insect Physiology·Claude Wicker-Thomas, Mickael Hamann
Oct 10, 2006·Insect Biochemistry and Molecular Biology·Sonja GerberChristian Wolf
Jul 30, 2005·Pharmacology, Biochemistry, and Behavior·Robert G PendletonRalph Hillman
Jun 26, 2007·Developmental Biology·Anita HsounaJanis M O'Donnell
Mar 6, 2007·Genesis : the Journal of Genetics and Development·Robert PendletonRalph Hillman
Aug 12, 2000·Journal of Neurogenetics·S KrishnakumarJ O'Donnell
Apr 29, 2014·Experimental Animals·Shinya Yamamoto, Elaine S Seto
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Robert G PendletonRalph Hillman
Feb 18, 2015·The Journal of Experimental Biology·Yasukazu OkadaToru Miura
Mar 23, 2010·Journal of Insect Physiology·Shinya AkasakaTakashi Nagao

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