PMID: 3760741Sep 1, 1986Paper

Reproduction in the vervet monkey (Cercopithecus aethiops): endometrial oestrogen and progestin receptor dynamics during normal and prolonged menstrual cycles

The Journal of Endocrinology
G B KudoloR M Eley

Abstract

Sixteen individually caged adult female vervet monkeys (Cercopithecus aethiops), whose reproductive parameters had been studied for 5 years, were hysterectomized/ovariectomized during three reproductive states; i.e. the late follicular (15.4 +/- 4.7 (S.D.) days) and luteal (27.8 +/- 4.7 days) phases of the normal cycle (20-50 days), and during prolonged intermenstrual intervals (PII; 99.0 +/- 2.5 days since the previous menses). These latter animals showed characteristics of both follicular and luteal phases; i.e. their ovaries contained both corpora lutea and large antral follicles and systemic oestradiol and progesterone concentrations were raised. Analysis of cytoplasmic oestrogen and progestin receptors (CER and CPR) revealed that endometrium during PII had CER levels of 0.58 +/- 0.07 pmol/mg protein, similar to those of the follicular phase (0.60 +/- 0.12); CPR levels (1.20 +/- 0.87) were not different from those of the luteal phase (1.05 +/- 0.45). The ratio of CPR to CER during the luteal phase was about tenfold higher than that of the follicular phase. Levels during PII were intermediate between the two phases. Under receptor-activating conditions, the DNA-binding components of the PII cytoplasmic fraction underwent ove...Continue Reading

Citations

Feb 13, 2007·American Journal of Primatology·Rebecca L CarrollOv D Slayden
Jan 1, 1989·American Journal of Primatology·R M EleyJ G Else
Feb 13, 2007·American Journal of Primatology·Theodore A MolsknessRichard L Stouffer

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