Reproductive and immune responses to photoperiod and melatonin are linked in Peromyscus subspecies

Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology
G E DemasRandy J Nelson

Abstract

The effects of photoperiod and melatonin treatment on reproductive and immune function were assessed in two subspecies of Peromyscus maniculatus from different latitudes of origin. In experiment 1, P. m. bairidii (latitude = 42 degrees 51' N) and P. m. luteus (latitude = 30 degrees 37' N) were housed in either long (LD 16:8) or short days (LD 8:16) for 8 weeks. Short-day P. m. bairdii displayed reproductive regression and elevated splenocyte proliferation in response to the T-cell mitogen concanavalin A, as compared to long-day mice. In contrast, P. m. luteus did not undergo reproductive regression or exhibit any increase in lymphocyte proliferation in short days. In experiment 2, individuals of both P. m. bairdii and P. m. luteus were implanted with empty capsules or capsules that contained melatonin. Individual P. m. bairdii implanted with melatonin underwent reproductive regression. Individuals of this subspecies also displayed elevated lymphocyte proliferation compared to control mice. Conversely, P. m. luteus implanted with melatonin did not undergo reproductive regression and displayed no significant changes in lymphocyte proliferation. These results suggest that reproductive responsiveness to melatonin mediates short-day...Continue Reading

Citations

Feb 11, 2003·Physiology & Behavior·Steven G KinseyRandy J Nelson
Jan 1, 1997·Brain Research Bulletin·R J Nelson, G E Demas
Aug 12, 1998·Proceedings. Biological Sciences·G E BentleyG F Ball
Oct 25, 2001·Proceedings. Biological Sciences·B J Prendergast, R J Nelson
Jul 20, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lynn B MartinRandy J Nelson
Sep 24, 1998·Journal of Pineal Research·T H ChampneyL A Beausang
Nov 22, 2007·Ecology·Lynn B MartinRandy J Nelson
Jul 7, 2007·The European Journal of Neuroscience·Brian C TrainorRandy J Nelson
Mar 16, 2011·The Journal of Animal Ecology·Gregory E DemasSusannah S French
Feb 14, 2012·Brain, Behavior, and Immunity·Laura K FonkenRandy J Nelson
Dec 3, 2014·Frontiers in Neuroendocrinology·Zachary M WeilRandy J Nelson
Jun 28, 2016·Seminars in Cell & Developmental Biology·Jeremy C Borniger, Randy J Nelson
Feb 28, 2003·Biology of Reproduction·Ganapathy K BhatDavid R Mann
Oct 12, 2002·Journal of Biological Rhythms·Randy J Nelson, Brian J Prendergast
Feb 12, 2002·Journal of Biological Rhythms·S M Yellon, L T Tran
Apr 30, 2020·International Reviews of Immunology·Alex ShneiderAnna Vakhrusheva
Jun 15, 2001·ILAR Journal·Charlotte P. JoynerWallace D. Dawson
Jan 14, 1999·The American Journal of Physiology·S M YellonS L Nehlsen-Cannarella
Oct 6, 2020·Frontiers in Endocrinology·Zeeshan Ahmad KhanAsamanja Chattoraj
Sep 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregory E DemasDeborah L Drazen
Dec 31, 1997·The American Journal of Physiology·G E DemasR J Nelson

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