Reproductive and neurobehavioral effects of Allura Red AC administered to mice in the diet

Toxicology
T Tanaka

Abstract

The color additive, Allura Red AC, was given in the diet to provide levels of 0.42, 0.84, and 1.68% (control, 0%), from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were few adverse effects of Allura Red AC on either litter size or weight, and ratio of male to female was significantly reduced in the lowest dosed group. Average body weight of offspring during the lactation period was significantly increased in the lower dosed groups of each sex. As regards the neurobehavioral parameters, no adverse effect was observed in the behavioral development during lactation period. There were few adverse effects of Allura Red AC on either movement activity or maze learning in F1 generation mice, compared with controls in each sex. The dose levels of Allura Red AC in the present study (approximately 86-1430 times greater than human ADI) produced few adverse effects in reproductive and neurobehavioral parameters in mice.

References

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Citations

Mar 1, 1996·Cellular Signalling·K Sandau, B Brüne
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C ReynosoE G de Mejia
Jan 6, 1999·Reproductive Toxicology·T Tanaka
Sep 25, 2003·Bioorganic & Medicinal Chemistry Letters·Kamil KucaJirí Kassa
Mar 4, 2008·Biological & Pharmaceutical Bulletin·Kanako SatohFumiko Nagai
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tuomas TallinenL Mahadevan
Feb 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Betul Mermi CeyhanEsin Kulac
Oct 19, 2005·Journal of Occupational Health·Sunil KumarHabibullah N Saiyed
Feb 11, 2012·Toxicology and Industrial Health·Duygu Kumbul DogucFatih Gultekin
Apr 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Grace ChappellSusan Borghoff
Mar 8, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robinan GentryHarvey Clewell
Apr 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robinan GentryAleksandra Mostrag

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