Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation.

Blood
Tanya BurkholderDennis D Hickstein

Abstract

Nonmyeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis of reproductive function. To address the question of reproductive function after nonmyeloablative transplantation, we analyzed a cohort of young dogs with the genetic disease canine leukocyte adhesion deficiency that were treated with a nonmyeloablative dose of 200 cGy total body irradiation followed by matched-littermate SCT. Five males and 5 females entered puberty; all 5 males and 4 females subsequently sired or delivered litters following transplantation. We demonstrate that fertility is intact and dogs have uncomplicated parturitions following nonmyeloablative conditioning for SCT. These results are encouraging for children and adults of childbearing age who receive similar conditioning regimens prior to allogeneic transplantation.

References

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Citations

Mar 7, 2012·Expert Review of Clinical Immunology·Robert Chiesa, Paul Veys
May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·Mary C DeBey
Mar 24, 2010·Pediatric Clinics of North America·Paul SzabolcsPaul Veys
Feb 2, 2010·Immunology and Allergy Clinics of North America·Paul Veys
Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William H PeranteauAlan W Flake
Mar 28, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thomas R BauerDennis D Hickstein

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