Reproductive characteristics and risk of uterine leiomyomata.

Fertility and Sterility
Kathryn L TerryStacey A Missmer

Abstract

To evaluate whether menstrual and reproductive characteristics may influence development of uterine leiomyomata since sex steroid hormones have been hypothesized to play a role in their development. A prospective cohort study (Nurses' Health Study II). Participants were identified from 14 states and followed for 14 years. A cohort of 116,609 female registered nurses ages 25-42 at baseline. We obtained data on uterine leiomyomata incidence and exposures through biennial questionnaires. We calculated hazard ratios and 95% confidence intervals adjusted for known and suspected risk factors. Uterine leiomyomata confirmed by ultrasound or hysterectomy. During 1,163,439 person-years of follow-up, 9,847 self-reported cases of hysterectomy- or ultrasound-confirmed uterine leiomyomata were reported. We observed a lower incidence of uterine leiomyomata with later age at menarche, longer menstrual cycles, parity, later age at first and last birth, shorter time since last birth, and breastfeeding. Hormonal and anatomical changes associated with menstruation and pregnancy may influence uterine leiomyomata incidence.

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Citations

Oct 24, 2012·Annals of Epidemiology·Lauren A WiseLynn Rosenberg
Aug 16, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sara M Drayer, William H Catherino
Nov 4, 2015·Archives of Gynecology and Obstetrics·Hans-Joachim AhrendtDolores Foth
Jul 28, 2016·American Journal of Public Health·Jorge E ChavarroStacey A Missmer
Mar 16, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·E A StewartR Schulze-Rath
Sep 21, 2017·International Journal of Molecular Sciences·Veronica SaraisPaola Vigano'
Dec 17, 2015·Clinical Obstetrics and Gynecology·Dima Ezzedine, Errol R Norwitz
Jul 14, 2019·Scientific Reports·Giovanni Delli CarpiniAndrea Ciavattini
Jun 10, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Toshiyuki YasuiShosuke Suzuki
Jan 9, 2019·Frontiers in Genetics·Ghada M A AjabnoorNoor Ahmad Shaik
Jan 9, 2016·Clinical Obstetrics and Gynecology·Lauren A Wise, Shannon K Laughlin-Tommaso
Feb 9, 2021·Frontiers in Genetics·Irina PonomarenkoMikhail Churnosov
Aug 28, 2021·Current Issues in Molecular Biology·Piotr RubiszChristopher Kobierzycki

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