Reproductive counselling, treatment and course of pregnancy in 73 German MS patients

Acta Neurologica Scandinavica
Kerstin HellwigRalf Gold

Abstract

Multiple sclerosis (MS) often affects women during the reproductive years of their life. During this period, issues such as choice of immunomodulatory treatment, seeking advice from specialists, relapse-induced steroid application before, during or after pregnancy in combination with breastfeeding gain importance. The objective was to investigate these issues retrospectively using a questionnaire among 73 MS patients with a total of 88 pregnancies. Eighty per cent of the participants consulted their neurologists before and 60% during pregnancy. The annual relapse rate decreased during pregnancy and significantly increased during the first 3 months after delivery. Immunomodulatory treatment was stopped due to desired pregnancy for a mean of 4 years. Fourteen of the MS patients received intravenous immunoglobulin treatment post-natal. Ninety per cent of the study subjects started breastfeeding. However, nearly 30% ablactated, as they received steroids due to a relapse. Weight and height of the full-term children of singleton pregnancies from MS patients were significantly lower compared with the ones of age-matched healthy controls. Our results confirm the known reduced relapse rate during pregnancy, which is followed by an incre...Continue Reading

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Citations

Feb 26, 2009·Journal of Neurology·Kerstin HellwigRalf Gold
Nov 26, 2009·Journal of Neurology·Kerstin HellwigRalf Gold
Sep 14, 2012·Therapeutic Advances in Neurological Disorders·Kerstin HellwigRalf Gold
Dec 2, 2010·Women's Health·Céline JobinPierre Duquette
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Jul 29, 2021·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Natalie V ScimeKathleen H Chaput

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