PMID: 9535506Apr 16, 1998Paper

Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats

Reproductive Toxicology
M EmaK Kawashima

Abstract

In our previous studies, butyl benzyl phthalate (BBP) was found to be embryolethal and teratogenic in rats. In this study, the reproductive effects of BBP were investigated in pregnant and pseudopregnant rats. Rats were given BBP by gastric intubation at 0, 250, 500, 750, or 1000 mg/kg on Days 0 to 8 of pregnancy and the pregnancy outcome was determined on Day 20 of pregnancy. The same doses of BBP were given to pseudopregnant rats, with an induced decidual cell response on Days 0 to 8 of pseudopregnancy, and the uterine weight on Day 9 served as an index of the uterine decidualization. BBP caused significant increases in the incidences of preimplantation loss in females successfully mated at 1000 mg/kg and of postimplantation loss in females having implantations at 750 mg/kg and above. Uterine decidual growth in pseudopregnant rats was significantly decreased at 750 mg/kg and above. These findings suggest that early embryonic loss due to BBP may be mediated, at least in part, via the suppression of uterine decidualization, an impairment of uterine function.

References

Feb 1, 1992·Journal of Applied Toxicology : JAT·M EmaH Kawasaki
Jun 1, 1992·Journal of Applied Toxicology : JAT·M EmaH Kawasaki
Oct 1, 1990·Journal of Applied Toxicology : JAT·M EmaH Kawasaki
Oct 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A M Cummings
Jun 1, 1973·Environmental Health Perspectives·J Autian
Aug 18, 1972·Nature·F L MayerJ L Johnson
Jul 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·Q Q BuiW L West
Feb 1, 1995·Archives of Environmental Contamination and Toxicology·M EmaY Ogawa
Feb 1, 1995·Bulletin of Environmental Contamination and Toxicology·G H Tan
May 1, 1994·Reproductive Toxicology·M EmaY Ogawa
Jul 1, 1962·Endocrinology·J M YOCHIM, V J DE FEO

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Citations

Nov 12, 2013·Environmental Science and Pollution Research International·Rahish AhmadSunil Kumar
Mar 17, 2004·Reproductive Toxicology·Rochelle W TylJohn H Butala
May 1, 2009·Human and Ecological Risk Assessment : HERA·Xiaoyong YanMark G Robson
Oct 20, 2005·Occupational and Environmental Medicine·R Hauser, A M Calafat
Feb 27, 2010·Environmental Health Perspectives·Jennifer WeuveLauren A Wise
Jan 5, 2011·Frontiers in Bioscience (Elite Edition)·Jared C RobinsSurendra S Sharma
Jan 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alzbeta MlynarcíkováSona Scsuková
Aug 29, 2003·Biochemical and Biophysical Research Communications·Subhankar Chatterjee, Tapan K Dutta
Dec 22, 2009·Congenital Anomalies·Tetsuji Nagao, Shinsuke Yoshimura
Feb 15, 2013·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Apr 28, 2006·The Journal of Toxicological Sciences·Sunao AsoYasusi Minobe
Apr 28, 2006·The Journal of Toxicological Sciences·Hiroaki AoyamaShoji Teramoto
Feb 24, 2015·Frontiers in Endocrinology·Patrick R Hannon, Jodi A Flaws
Jul 18, 2016·Environment International·Melissa MarianaElisa Cairrao
Nov 30, 2011·International Journal of Toxicology·F Alan Andersen
Mar 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sapna SedhaVivek K Bajpai

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