Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses.

Reproductive Sciences
Ceyhan HaciogluGungor Kanbak

Abstract

Aging is a natural process in which morphological and functional abnormalities in living organisms increase irreversibly. Nicotinamide (NAM) acts both as a precursor of many metabolites and as a cofactor of many enzymes involved in cell energy metabolism, homeostasis of redox balance, and regulation of signaling pathways. In this study, we investigated the effects of NAM treatment on morphological and biochemical changes in testis of old rats. The rats were treated with 200, 400, and 800 mg/kg NAM doses as a gavage for 1 month. As a result, we determined the dose-dependent therapeutic effects of NAM on testicular tissues of aged rats. We found that NAM treatment decreased total oxidant status (TOS), caspase 3 (CASP3) and cytochrome c (CYC) levels and increased total antioxidant status (TAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels (P<0.05). NAM treatment significantly reduced the age-related histopathological parameters such as cellular loss, necrotic tissue, interstitial edema, tubular damage, and vascular congestion in aged rat testicular tissue compared to the control group. Moreover, based on histomorphological analysis, we detected that NAM treatment resulted in a dose-dependen...Continue Reading

References

Apr 10, 1996·Neuroreport·G TaglialatelaG M Rose
May 5, 1998·The Anatomical Record·C S Adams, W E Horton
Mar 8, 1999·Molecular Cell Biology Research Communications : MCBRC·A A Kapasi, P C Singhal
Mar 4, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·D NakaeY Konishi
Jul 27, 2000·Annals of the New York Academy of Sciences·C PetropoulouE S Gonos
Oct 30, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Pollack, C Leeuwenburgh
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon Phaneuf, Christiaan Leeuwenburgh
Oct 31, 2002·Metabolism: Clinical and Experimental·Robert W PowersJames M Roberts
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·A M MahmoudJ M Kaufman
Aug 23, 2003·International Journal of Impotence Research·J S Tenover
Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Luchuan CaoSalman Azhar
Apr 12, 2005·Fertility and Sterility·Mbarka DakouaneJacqueline Selva
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Toren Finkel
Aug 31, 2006·Aging Cell·Hyun Tae KangEun Seong Hwang
Apr 27, 2007·Annals of the New York Academy of Sciences·Syed Ibrahim Rizvi, Pawan Kumar Maurya
Jun 16, 2007·Cellular Signalling·Marcelo Genestra
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Oct 14, 2010·Journal of Cell Science·Arnold Y SeoChristiaan Leeuwenburgh
Oct 17, 2012·The Journal of Cell Biology·Riekelt H Houtkooper, Johan Auwerx
Feb 23, 2013·Mechanisms of Ageing and Development·Kimberly D JacobMichele K Evans
Jul 10, 2013·Experimental Gerontology·Tiago Boeira SalomonMara Silveira Benfato
Sep 27, 2014·International Journal of Molecular Sciences·Xinhui WangAlan R Parrish
Dec 3, 2014·Ageing Research Reviews·Sheri L JohnsonShinichi Nakagawa
Dec 17, 2014·Nursing Research·Dereck Salisbury, Ulf Bronas
Feb 11, 2015·The International Journal of Biochemistry & Cell Biology·Valerio CarelliMichela Rugolo
Feb 24, 2015·Experimental Gerontology·M C BeattieB R Zirkin
May 6, 2015·European Journal of Medicinal Chemistry·Aurelia Magdalena Pisoschi, Aneta Pop
Jun 16, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ron GolanRanjith Ramasamy
Oct 23, 2015·Disease-a-month : DM·Martin S Lipsky, Mitch King
Dec 22, 2015·Cell Metabolism·Christopher D WileyJudith Campisi
Feb 13, 2016·Journal of Assisted Reproduction and Genetics·Sezgin GunesRamazan Asci
Mar 1, 2016·Mechanisms of Ageing and Development·Yujia YuanYanrong Lu
Nov 27, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lei XieYu Liang
Mar 2, 2017·International Journal of Molecular Sciences·Shigehisa YanagiMasamitsu Nakazato
May 26, 2017·Biogerontology·O S AdemowoH R Griffiths
Jul 28, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Yiyan WangHaolin Chen
Sep 14, 2017·Trends in Molecular Medicine·Evandro F FangVilhelm A Bohr
Nov 22, 2017·Acta Cirúrgica Brasileira·Bruno Vinicius Duarte NevesRogério de Fraga
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha

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