Reproductive endocrine and endometrial effects of raloxifene hydrochloride, a selective estrogen receptor modulator, in women with regular menstrual cycles

The Journal of Clinical Endocrinology and Metabolism
V L BakerR B Jaffe

Abstract

Previous studies of raloxifene conducted in animal models and postmenopausal women have demonstrated antiestrogenic action on the endometrium. The purpose of this first study of raloxifene in women with normal menstrual cycles was to determine its reproductive endocrine and endometrial effects. In part I, raloxifene (400 mg) was administered for 5 days in the follicular, periovulatory, or luteal phase of the menstrual cycle (n = 12). In part II, women were randomized to receive raloxifene (100 or 200 mg) for 28 days beginning on day 3 of the cycle (n = 19). All women ovulated in both parts of the study. Raloxifene did not alter the length of the menstrual cycle or the day of the LH surge. A 5-day course of raloxifene administered in any phase of the cycle elevated FSH area under the curve (AUC) for the entire cycle and estradiol AUC for the second half of the cycle compared with those in control cycles. In part II, raloxifene also appeared to increase the FSH AUC and estradiol AUC. Raloxifene decreased the number of gland mitoses in follicular phase endometrial biopsies. Subtle effects suggestive of gland-stromal dysynchrony were noted in a limited number of the secretory phase endometrial biopsies. This study has demonstrated ...Continue Reading

References

Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·A R Midgley, R B Jaffe
Apr 1, 1995·Pharmacology·M W DraperR L Zerbe
Jan 1, 1996·Obstetrical & Gynecological Survey·V L Baker, R B Jaffe
Jun 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M W DraperC Arnaud

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Citations

Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J AnD C Leitman
Nov 26, 2010·Human Reproduction Update·Pamela Stratton, Karen J Berkley
Jan 1, 2008·Obstetrics and Gynecology·Pamela StrattonLynnette K Nieman
Oct 26, 1999·Journal of Endocrinological Investigation·M Dören
Mar 5, 2004·Surgical Oncology·J M Dixon
Apr 26, 2007·Protein Science : a Publication of the Protein Society·Felix F VajdosJayvardhan Pandit
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brigitte UebelhartRené Rizzoli
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carol J Fabian, Bruce F Kimler
Jun 16, 1999·Endocrine Reviews·F Cosman, R Lindsay
Jun 16, 1999·Endocrine Reviews·V C Jordan, M Morrow
Oct 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Karen A Johnson
Jan 5, 2007·Gynecologic and Obstetric Investigation·Sun-Wei Guo, David L Olive
Nov 18, 2000·Thyroid : Official Journal of the American Thyroid Association·A W KungL D Kohn
Mar 14, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chitra ChoudharyGeorgiana Dobri

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