Reproductive Endocrinology Reference Intervals for Transgender Women on Stable Hormone Therapy.

The Journal of Applied Laboratory Medicine
Dina N GreeneMatthew D Krasowski

Abstract

Transgender women and nonbinary people seeking feminizing therapy are often prescribed estrogen as a gender-affirming hormone, which will alter their reproductive hormone axis. Testosterone, estradiol, and other reproductive hormones are commonly evaluated to assess therapy, but reference intervals specific to transgender women have not been established. The objective of this study was to derive reference intervals for commonly measured analytes related to reproductive endocrinology in a cohort of healthy gender nonconforming individuals on stable feminizing hormone therapy. Healthy transgender individuals who had been prescribed estrogen (n = 93) for at least a year were recruited from internal medicine and primary care clinics that specialize in transgender medical care. Total testosterone and estradiol were measured using immunoassay and mass spectrometry; LH, FSH, sex hormone binding globulin, prolactin, progesterone, anti-mullerian hormone (AMH), and dehydroepiandrosterone sulfate (DHEAS) were measured using immunoassay; free testosterone was calculated. Reference intervals (central 95%) were calculated according to Clinical Laboratory Standards Institute guidelines. The distribution of results for transgender women was di...Continue Reading

References

Mar 11, 2005·European Journal of Endocrinology·Lam P Ly, David J Handelsman
Jan 11, 2014·Asian Journal of Andrology·Hubert W VesperYuesong Wang
Apr 17, 2015·European Journal of Endocrinology·Angela E TaylorIlpo T Huhtaniemi
Dec 6, 2016·The Lancet. Diabetes & Endocrinology·Vin Tangpricha, Martin den Heijer
Sep 26, 2017·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeGuy G T'Sjoen
Apr 25, 2018·Brain : a Journal of Neurology·Nienke M NotaMartin den Heijer
Jul 27, 2018·Critical Reviews in Clinical Laboratory Sciences·Yesim OzardaUNKNOWN IFCC Committee on Reference intervals and Decision Limits (C-RIDL)
Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Jerilynn C Prior
Feb 17, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dina N GreeneMatthew D Krasowski
Mar 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Sean J IwamotoMicol S Rothman

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Citations

Mar 26, 2021·Clinical Pharmacology and Therapeutics·Lauren R Cirrincione, Kai J Huang

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