Reproductive experience alters anxiety-like behavior in the female rat

Hormones and Behavior
Elizabeth M Byrnes, Robert S Bridges

Abstract

Reproductive experience (i.e. pregnancy and lactation) results in significant alterations in subsequent hormone levels in female rats. Several studies have demonstrated that circulating hormones can significantly affect anxiety-like behavior. Thus, the purpose of the present study was to determine whether reproductive experience induces alterations in anxiety-like behaviors in cycling female rats and in older, reproductively senescent rats. In Experiment 1, the elevated plus maze (EPM) was used to test young cycling (6-8 weeks post-weaning) and middle-aged (32-36 weeks post-weaning) primiparous rats and their age-matched nulliparous counterparts for anxiety-like responses. In Experiment 2, activity in the open field was used as an additional measure of anxiety-like behavior in young (proestrus) and middle-aged (constant estrus) primiparous and nulliparous rats. For Experiment 3, EPM testing was conducted in separate groups of young and middle-aged animals tested two weeks after ovariectomy. The results revealed that during proestrus, primiparous animals exhibited fewer anxiety-like behaviors on the EPM compared to nulliparous controls. In middle-aged animals, however, parity was associated with increased anxiety-like behavior. ...Continue Reading

References

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Jan 16, 2002·Physiology & Behavior·F K MarcondesR C Spadari-Bratfisch
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Mar 31, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
May 10, 2005·Hormones and Behavior·Elizabeth M Byrnes, Robert S Bridges

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Citations

Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Jason J Paris, Cheryl A Frye
Apr 1, 2012·The Journal of General Psychology·Karin J BodensteinerStephanie S Miner
Jul 1, 2015·Hormones and Behavior·Jodi L PawluskiCraig H Kinsley
Apr 13, 2010·Neurotoxicology and Teratology·Sherry A Ferguson, Kimberly J Berry
Sep 19, 2009·Neuroscience and Biobehavioral Reviews·Abbe H Macbeth, Victoria N Luine
Apr 7, 2009·Pharmacology, Biochemistry, and Behavior·Tamara L Doremus-FitzwaterLinda Patia Spear
Mar 4, 2008·Physiology & Behavior·Natalia UriarteAldo B Lucion
Oct 16, 2007·Physiology & Behavior·Alicia A Walf, Cheryl A Frye
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Jan 17, 2013·Nutritional Neuroscience·Elizabethe Cristina BorsoneloJosé Carlos Fernandes Galduróz
Feb 24, 2015·Trends in Neurosciences·Jack A PrendervilleJohn F Cryan
Sep 2, 2008·Behavioural Brain Research·Jodi L PawluskiLiisa A M Galea
Oct 8, 2016·The European Journal of Neuroscience·Roshan R Naik, Trynke R de Jong
Apr 17, 2018·Endocrinology·Sharon Rachel LadymanDavid Ross Grattan
Jun 6, 2019·G3 : Genes - Genomes - Genetics·Michelle N Arbeitman
Dec 12, 2018·Hormones and Behavior·Moriah R ArnoldSarah H Meerts

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