Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort

Cancer Causes & Control : CCC
Gibson Ming Wei GayWei-Yen Lim

Abstract

The aim of this study was to assess associations of breastfeeding, adiposity and reproductive risk factors with ovarian cancer risk in a Singaporean population. In addition to the main analysis, interaction effects of parity on other risk factors were examined. A retrospective cohort consisting of 28,201 women with 107 incident ovarian cancers in up to 17 years of follow-up from the Singapore Breast Cancer Screening Project (1994-1997) was studied. Hazard ratios (HRs) for risk factors were estimated using Cox proportional hazards models. Body mass index and breastfeeding were found to have no statistical significant association with ovarian cancer risk. Gravidity was inversely associated with ovarian cancer risk [each pregnancy, adjusted HR 0.89, 95% confidence interval (CI) 0.81, 0.97], while results for parity were very similar (per delivery, HR 0.89, 95% CI 0.81, 0.98). Each additional year of ovulatory period was found to increase ovarian cancer risk by 2% (HR 1.02, 95% CI 1.00, 1.04). Each year increase in total duration of oral contraceptive use reduced ovarian cancer risk by 6% (HR 0.94, 95% CI 0.85, 1.02). Parity, gravidity and shorter ovulatory period were associated with lower ovarian cancer risk. Breastfeeding and bo...Continue Reading

References

Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·L A Lesoon, V B Mahesh
Jun 22, 1991·Lancet·S LowryR Atkinson
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·S FranceschiV Beral
May 1, 1988·American Journal of Epidemiology·P HartgeH J Norris
Jul 17, 1971·Lancet·M F Fathalla
Jan 1, 1981·Annual Review of Biochemistry·J G Pierce, T F Parsons
Oct 1, 1994·American Journal of Epidemiology·H A RischG R Howe
May 5, 2001·Epidemiology·R B NessUNKNOWN Study of Health and Reproduction (SHARE) Study Group
Nov 21, 2001·Cancer Causes & Control : CCC·D M PurdieA C Green
May 10, 2002·Reproduction, Fertility, and Development·A S McNeilly
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·David M PurdieAdèle C Green
Aug 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Tomas RimanIngemar R Persson
Nov 22, 2005·Molecular and Cellular Endocrinology·Jean S FlemingOlivia L Tan
Dec 20, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·R Sankaranarayanan, J Ferlay
Apr 6, 2006·Cancer·Julia B GreerGlenn O Allen
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn L TerryDaniel W Cramer
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Catherine M OlsenPenelope M Webb
Sep 26, 2009·Cancer Causes & Control : CCC·Susan J JordanPenelope M Webb
Nov 11, 2009·Cancer Causes & Control : CCC·Linda Titus-ErnstoffDaniel W Cramer
Nov 17, 2009·American Journal of Epidemiology·Margaret A GatesShelley S Tworoger
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Oct 1, 2011·International Journal of Cancer. Journal International Du Cancer·Hannah P YangNicolas Wentzensen
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
Feb 5, 2013·Cancer Causes & Control : CCC·Tess V ClendenenAnne Zeleniuch-Jacquotte
May 8, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hannah P YangMark E Sherman
Jul 4, 2013·British Journal of Cancer·C BodelonR M Pfeiffer
Aug 24, 2013·The American Journal of Clinical Nutrition·Nan-Nan LuanBei Lin
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jalal PoorolajalSeyyedeh Zahra Masoumi

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Citations

Mar 23, 2017·Antioxidants & Redox Signaling·Amy J BurkeSharon A Glynn
Jul 20, 2017·Post Reproductive Health·Ke Wei Foong, Helen Bolton

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