Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative

Journal of the American College of Cardiology
Philip S HallNisha I Parikh

Abstract

Reproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac remodeling and the development of heart failure (HF). This study examined the association between key reproductive factors and the incidence of HF. Women from a cohort of the Women's Health Initiative were systematically evaluated for the incidence of HF hospitalization from study enrollment through 2014. Reproductive factors (number of live births, age at first pregnancy, and total reproductive duration [time from menarche to menopause]) were self-reported at study baseline in 1993 to 1998. We employed Cox proportional hazards regression analysis in age- and multivariable-adjusted models. Among 28,516 women, with an average age of 62.7 ± 7.1 years at baseline, 1,494 (5.2%) had an adjudicated incident HF hospitalization during an average follow-up of 13.1 years. After adjusting for covariates, total reproductive duration in years was inversely associated with incident HF: hazard ratios (HRs) of 0.99 per year (95% confidence interval [CI]: 0.98 to 0.99 per year) and 0.95 per 5 years (95% CI: 0.91 to 0.99 per 5 years). Conversely, early age at first pregnancy and nulliparity were significantly associated with incident HF in age-adju...Continue Reading

Citations

Aug 22, 2018·Menopause : the Journal of the North American Menopause Society·Cynthia A Stuenkel
Nov 19, 2019·JAMA : the Journal of the American Medical Association·Michael C HonigbergPradeep Natarajan
Sep 23, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jian-Shu ChenJing Yu
Jun 18, 2020·International Journal of General Medicine·Anita Deborah AnwarElsy Nur Anggraeni
Dec 5, 2019·European Journal of Preventive Cardiology·Andrew ConstantineAli Vazir
Jan 30, 2020·Frontiers in Endocrinology·Leanne GrobanSarah H Lindsey
Apr 10, 2021·ESC Heart Failure·Dongling LuoCaojin Zhang
Aug 18, 2021·The Canadian Journal of Cardiology·Geoffrey H TisonNisha I Parikh
Aug 17, 2021·JACC. CardioOncology·Phillip H LamSelma F Mohammed
Oct 28, 2017·Journal of the American College of Cardiology·Ibrahim El-BattrawyIbrahim Akin
Oct 28, 2017·Journal of the American College of Cardiology·Nisha I Parikh, Philip S Hall
Oct 7, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Alison Gemmill, Jordan Weiss

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