Reproductive factors and molecular subtypes of breast cancer among premenopausal women in Latin America: the PRECAMA study

Scientific Reports
Isabelle RomieuPRECAMA team

Abstract

Etiological differences among breast cancer (BC) subtypes have not been clearly established, especially among young women in Latin America. This study examined the relationship between reproductive factors and BC subtypes among 288 BC cases (20-45 years) and population-based matched controls in four Latin American countries. Immunohistochemistry was determined centrally. Associations between BC and reproductive factors were determined. Older age at first full-term pregnancy (FFTP) (Odds Ratio (OR) = 1.11; 95% Confidence Interval (CI), 1.04-1.19 per year), longer time between menarche and FFTP (OR = 1.12; 95%CI: 1.04-1.20 per year), and older age at last pregnancy (OR = 1.10; 95%CI, 1.02-1.19 per year) were associated with an increased risk of estrogen receptor positive (ER+) tumors (n = 122). Ever pregnant (OR = 0.35; 95%CI, 0.13-0.96), number of childbirths (OR = 0.64; 95%CI, 0.47-0.87 per child), time since last birth (OR = 0.92; 95%CI, 0.85-0.99 per year), and history of breastfeeding (OR = 0.23; 95%CI, 0.09-0.58) were inversely associated with the risk of ER+ tumor. Older age at menarche (OR = 0.63; 95%CI, 0.45-0.89 per year) and longer duration of breastfeeding (OR = 0.97; 95%CI, 0.94-1.01 per month) were inversely associa...Continue Reading

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Citations

Feb 20, 2019·Genes·Valentina A ZavalaLaura Fejerman
Feb 8, 2020·Technology in Cancer Research & Treatment·Zhun YuGuoping Xu
Sep 10, 2020·British Journal of Cancer·Valentina A ZavalaLaura Fejerman
Feb 23, 2020·Breast Cancer Research and Treatment·Elodia Rojas-LimaLizbeth López-Carrillo
Feb 2, 2020·Journal of Cancer Research and Clinical Oncology·Erica SilvestrisStella D'Oronzo
Aug 3, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yanjun WuDongfeng Zhang
Nov 26, 2020·International Journal of Molecular Sciences·Nuri LeeSeri Jeong
Aug 29, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura Rey-VargasSilvia J Serrano-Gómez

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Methods Mentioned

BETA
biopsy

Software Mentioned

STATA
SAS

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