Reproductive factors and risk of biliary tract cancer in a population-based study

Acta Oncologica
Carl KilanderOmid Sadr-Azodi

Abstract

The strong female predominance of biliary tract cancer (BTC) may be related to reproductive factors. We aimed to clarify whether parity or age at first birth influence the risk of BTC. This was a population-based, case-control study including Swedish female and male cases of cancer of the gallbladder (GBC), extra hepatic bile ducts (EHCC), or the ampulla of Vater (AVC) between 1960 and 2008. For each case, 10 age- and sex-matched controls were randomly selected. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders. In total, 1169 cases of GBC, 432 cases of EHCC and 295 cases of AVC were included. Multi- and nulliparous women and men had an increased risk of all tumor locations in the biliary tract compared to uniparous women and men, respectively. Whereas higher age at first birth was associated with a decreased risk of GBC in women, no such association was found in men. There were no clear differences in the risk of EHCC and AVC between women and men. Sex hormones may play a role in the etiology of GBC. The associations between reproductive factors and EHCC and AVC are similar in women and men, which do not support the sex hormone hypoth...Continue Reading

References

May 30, 1991·International Journal of Cancer. Journal International Du Cancer·D M ParkinC P Wild
Mar 1, 1991·International Journal of Epidemiology·C La VecchiaP Boyle
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·H O AdamiL Bergkvist
Nov 15, 1985·International Journal of Cancer. Journal International Du Cancer·I PleskoJ Somogyi
Aug 1, 1994·International Journal of Epidemiology·G KvåleS Nilssen
May 1, 1994·Cancer Causes & Control : CCC·W H ChowT M Mack
Apr 15, 1994·International Journal of Cancer. Journal International Du Cancer·C J MoermanS Runia
Jan 1, 1994·American Journal of Epidemiology·R LuotoA Uutela
Jul 30, 1993·International Journal of Cancer. Journal International Du Cancer·M LambeM Pavia
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·C La VecchiaF Parazzini
Aug 1, 1996·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A TavaniC La Vecchia
Apr 27, 2001·American Journal of Epidemiology·E B GoldJ Skurnick
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Silvano GallusCarlo La Vecchia
Mar 8, 2003·The Lancet Oncology·Sanjeev MisraIndra D Sharma
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Esteve FernandezCarlo La Vecchia
Jan 7, 2006·International Journal of Cancer. Journal International Du Cancer·Giorgia RandiCarlo La Vecchia
Sep 4, 2008·Acta Oncologica·Lotti BarlowMats Talbäck
Mar 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ming-Hsi WangElizabeth A Platz
Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Aug 22, 2009·Journal of Surgical Oncology·Jorge Albores-SaavedraDonald E Henson
May 19, 2010·Gastroenterology Clinics of North America·Guy D Eslick
Oct 20, 2010·Best Practice & Research. Clinical Gastroenterology·Tom H KarlsenKirsten Muri Boberg
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Sep 22, 2011·Alimentary Pharmacology & Therapeutics·J R A SkipworthM Malagó
Jan 14, 2012·British Journal of Cancer·H NordenstedtJ Lagergren
May 24, 2012·International Journal of Cancer. Journal International Du Cancer·Sabrina SchlesingerUte Nöthlings
May 31, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S SchlesingerU Nöthlings

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