Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States

British Journal of Cancer
Grayson M DonleyElizabeth K Cahoon

Abstract

Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma. We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline. Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71; P for trend = 0.04) and late age at menopause (≥50 vs <45 years: HR = 1.34, 95% CI: 1.13, 1.59; P for trend = 0.001). The relationship between ambient UVR and melanoma risk was highest among women with age at menarche ≤10 years (HR per UVR quartile increase = 1.29; 95% CI: 1.05, 1.58; P-interaction = 0.02). Melanoma risk was not associated with parity, age at first birth, use of oral contraceptives or use of menopausal hormone therapy. Our findings suggest that increased melanoma risk is associated with early age at menarche and late age at menopa...Continue Reading

References

Jan 1, 1992·Maturitas·S M McKinlayJ G Posner
Sep 1, 1987·Journal of the American Academy of Dermatology·E A HollyS H Chiu
Jan 1, 1985·The Journal of Dermatologic Surgery and Oncology·D L EllisH Solomon
Feb 18, 1999·Toxicology Letters·R S Stern
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·B K Armstrong, A Kricker
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Aug 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David C WhitemanAdèle C Green
Mar 1, 2007·American Journal of Epidemiology·Jeanette KaaeMads Melbye
Nov 3, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E de VriesJ-W W Coebergh
Aug 30, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E R KoomenT Nijsten
Mar 26, 2009·Journal of the National Cancer Institute·Nadia HowladerBrenda K Edwards
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marit Bragelien VeierødElisabete Weiderpass
Mar 19, 2011·American Journal of Epidemiology·Marina KvaskoffFrançoise Clavel-Chapelon
May 31, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniSaverio Caini
Sep 1, 2011·Journal of the National Cancer Institute·Jean Y TangMarcia L Stefanick
Sep 13, 2011·Progress in Biophysics and Molecular Biology·Adèle C GreenPenelope McBride
Apr 28, 2012·International Journal of Cancer. Journal International Du Cancer·Shih-Wen LinChristian C Abnet
Jun 28, 2013·JAMA Dermatology·Christina S GambaSusan M Swetter
May 31, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shaowei WuAbrar A Qureshi
Mar 5, 2015·Cancer·Therese M-L AnderssonMats Lambe
Sep 5, 2015·Journal of Medical Genetics·Jazlyn ReadNicholas K Hayward
Sep 18, 2016·The British Journal of Dermatology·M A WeinstockA N A Tosteson
May 12, 2017·International Journal of Women's Dermatology·Mi Ryung RohHensin Tsao
Jul 8, 2017·International Journal of Cancer. Journal International Du Cancer·Edoardo BotteriElisabete Weiderpass
Aug 19, 2017·Endoscopic Ultrasound·UNKNOWN Chinese Thoracic Society, UNKNOWN Chinese Alliance against Lung Cancer
Aug 22, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·N A RicharzJ M Carrascosa

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Citations

Dec 6, 2019·Human Reproduction·B M HicksA Pottegård
Sep 12, 2019·International Journal of Cancer. Journal International Du Cancer·Iris CervenkaMarina Kvaskoff
Jul 11, 2020·Cancers·Maria BellenghiGianfranco Mattia
Nov 23, 2019·Cells·Emi DikaFederica Scarfì
Jul 24, 2020·Oncology and Therapy·Francesca MorgeseRossana Berardi
Jan 4, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L SaraswatS Bhattacharya

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Methods Mentioned

BETA
biopsy

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SAS

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